{"id":172,"date":"2016-11-19T16:50:06","date_gmt":"2016-11-19T13:50:06","guid":{"rendered":"http:\/\/werathah.com\/cancer\/?p=172"},"modified":"2017-08-05T16:50:49","modified_gmt":"2017-08-05T13:50:49","slug":"cancer-syndromes-summary","status":"publish","type":"post","link":"https:\/\/werathah.com\/cancer\/cancer-syndromes\/cancer-syndromes-summary\/","title":{"rendered":"\u0645\u062e\u062a\u0635\u0631 \u0639\u0646 \u0645\u062a\u0644\u0627\u0632\u0645\u0627\u062a \u0627\u0644\u0623\u0648\u0631\u0627\u0645"},"content":{"rendered":"

\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648\u0627\u0644\u0645\u0628\u064a\u0636 \u0627\u0644\u0648\u0631\u0627\u062b\u064a<\/span>
\n (Hereditary breast cancer and ovarian cancer syndrome<\/span>)<\/h1>\n

\u0623\u0634\u0647\u0631 \u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u0628\u0628 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0647\u0648 \u0645\u0627 \u064a\u0639\u0631\u0641 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648\u0627\u0644\u0645\u0628\u064a\u0636 \u0627\u0644\u0648\u0631\u0627\u062b\u064a .\u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0633\u0628\u0628\u0647 \u0637\u0641\u0631\u0629 \u0641\u064a \u0646\u0648\u0639\u064a\u0646 \u0645\u0634\u0647\u0648\u0631\u064a\u0646 \u0645\u0646 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u062a\u0633\u0645\u0649 \u0628\u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0623\u0648\u0644 \u0648 \u0627\u0644\u062b\u0627\u0646\u064a \u0645\u0646 \u0628\u064a \u0623\u0631 \u0633\u064a \u0623\u064a (BRCA1 and BRCA2) \u0648 \u0647\u064a \u062c\u064a\u0646\u0627\u062a \u0645\u0647\u0645\u0629 \u0644\u0625\u0635\u0644\u0627\u062d \u0627\u0644\u0623\u062e\u0637\u0627\u0621 \u0641\u064a \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u0642\u0637\u0639 \u0627\u0644\u0645\u0632\u062f\u0648\u062c \u0641\u064a \u0627\u0644\u062f\u064a \u0623\u0646 \u0623\u064a.<\/p>\n

\u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u0627\u062a\u064a \u064a\u0631\u062b\u0646 \u0647\u0630\u0627 \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0639\u0637\u0648\u0628 \u0644\u062f\u064a\u0647\u0646 \u0646\u0633\u0628\u0629 \u0627\u0639\u0644\u0649 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648 \u0627\u0644\u0645\u0628\u064a\u0636 \u062e\u0644\u0627\u0644 \u062d\u064a\u0627\u062a\u0647\u0646 \u0645\u0642\u0627\u0631\u0646\u0647 \u0628\u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u062a\u064a \u0644\u062f\u064a\u0647\u0646 \u0646\u0633\u062e\u0629 \u0633\u0644\u064a\u0645\u0629 .\u0643\u0645\u0627 \u0623\u0646 \u0627\u0644\u0631\u062c\u0627\u0644 \u0627\u0644\u0630\u064a\u0646 \u064a\u0631\u062b\u0648\u0646 \u0647\u0630\u0627 \u0627\u0644\u062c\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0646\u0633\u0628\u0629 \u0627\u0639\u0644\u0649 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648 \u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u062a\u0627 \u062e\u0644\u0627\u0644 \u062d\u064a\u0627\u062a\u0647\u0645 .\u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0627\u0644\u0649 \u0623\u0646 \u0628\u0639\u0636 \u0627\u0644\u0627\u0633\u0631 \u0644\u062f\u064a\u0647\u0645 \u0646\u0633\u0628\u0629 \u0627\u0639\u0644\u0649 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0648 \u0627\u0644\u0634\u0627\u0645\u0627\u062a \u0627\u0644\u062c\u0644\u062f\u064a\u0629 (\u0627\u0644\u0645\u064a\u0644\u0627\u0646\u0648\u0645\u0627).<\/p>\n

\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629: \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648\u0627\u0644\u0645\u0628\u064a\u0636 \u0627\u0644\u0648\u0631\u0627\u062b\u064a
\n\u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a: BRCA1 ,BRCA2
\n\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u0648\u0631\u0627\u0645: \u0628\u0634\u0643\u0644 \u0639\u0627\u0644\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648\u0627\u0644\u0645\u0628\u064a\u0636. \u0628\u0634\u0643\u0644 \u0627\u0642\u0644 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0648\u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u062a\u0627 \u0648\u0627\u0644\u0631\u062d\u0645 \u0648\u0627\u0644\u0634\u0627\u0645\u0627\u062a \u0627\u0644\u062c\u0644\u062f\u064a\u0629.<\/h3>\n

\u0646\u0633\u0628 \u0627\u0644\u0625\u0635\u0627\u0628\u0629:<\/h3>\n

\u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u0627\u062a\u064a \u0644\u062f\u064a\u0647\u0646 \u0637\u0641\u0631\u0629 \u0641\u064a BRCA1 \u0645\u0639\u0631\u0636\u0627\u062a \u0646\u0633\u0628\u0629 \u0639\u0627\u0644\u064a\u0629 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a (45 \u0627\u0644\u0649 80% \u062e\u0644\u0627\u0644 \u062d\u064a\u0627\u062a\u0647\u0645) \u0628\u0645\u0639\u062f\u0644 \u0633\u0646 \u0625\u0635\u0627\u0628\u0629 \u0641\u064a \u0627\u0644\u0627\u0631\u0628\u0639\u064a\u0646\u064a\u0627\u062a \u0648\u0628\u0646\u0633\u0628\u0629 \u062a\u0635\u0644 \u0627\u0644\u0649 55 % \u0627\u0644\u0649 65% \u0639\u0646\u062f \u0633\u0646 70 \u0639\u0627\u0645. \u0643\u0645\u0627 \u0627\u0646 \u0627\u062d\u062a\u0645\u0627\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u062b\u0627\u0646\u064a \u0628\u0627\u0644\u062b\u062f\u064a (\u0623\u0643\u062b\u0631 \u0645\u0646 50% \u062e\u0644\u0627\u0644 \u062d\u064a\u0627\u062a\u0647\u0645). \u0623\u064a\u0636\u0627 \u0644\u062f\u064a\u0647\u0646 \u062d\u0648\u0627\u0644\u064a 45% \u0627\u062d\u0645\u0627\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0628\u064a\u0636 \u062e\u0644\u0627\u0644 \u062d\u064a\u0627\u062a\u0647\u0646 \u0628\u0645\u0639\u062f\u0644 \u0633\u0646 \u0625\u0635\u0627\u0628\u0629 \u0641\u064a \u0627\u0644\u062e\u0645\u0633\u064a\u0646\u064a\u0627\u062a. \u0627\u0645\u0627 \u0627\u0644\u0627\u062a\u064a \u0644\u062f\u064a\u0647\u0646 \u0637\u0641\u0631\u0629 \u0641\u064a BRCA2 \u0644\u062f\u064a\u0647\u0646 \u0628\u0646\u0633\u0628\u0629 \u0639\u0627\u0644\u064a\u0629 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u062a\u0635\u0644 \u0627\u0644\u0649 45% \u0627\u0644\u0649 49% \u0639\u0646\u062f \u0633\u0646 70 \u0639\u0627\u0645\u060c \u0648\u0647\u0646 \u0627\u0642\u0644 \u0639\u0631\u0636\u0647 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0628\u064a\u0636 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0623\u0648\u0644 (\u062d\u0648\u0627\u0644\u064a 16%) \u0648\u0644\u0643\u0646 \u0633\u0646 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0623\u0643\u0628\u0631 \u0641\u064a \u0627\u0644\u0633\u062a\u064a\u0646\u064a\u0627\u062a. \u0627\u0644\u0627\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0644\u0644\u0631\u062c\u0627\u0644 \u0648\u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0648\u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u062a\u0627 \u064a\u062d\u062f\u062b \u0628\u0633\u0628\u0628 \u0637\u0641\u0631\u0629 \u0641\u064a \u0643\u0644\u0627 \u0627\u0644\u062c\u064a\u0646\u064a\u0646 \u0648 \u0644\u0643\u0646 \u0627\u0643\u062b\u0631 \u0641\u064a \u062c\u064a\u0646 BRCA2.<\/p>\n

\u0627\u0644\u0646\u0635\u0627\u0626\u062d \u0627\u0644\u0627\u0631\u0634\u0627\u062f\u064a\u0629:<\/h3>\n

\u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u0637\u0641\u0631\u0629 \u0641\u064a \u0623\u062d\u062f \u0647\u0630\u0647 \u0627\u0644\u062c\u064a\u0646\u064a\u0646 \u064a\u0646\u0635\u062d \u0628\u0625\u062c\u0631\u0627\u0621 \u0645\u0633\u062d \u0627\u0634\u0639\u0627\u0639\u064a (\u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a\u0629) \u0644\u0644\u062b\u062f\u064a (\u0627\u0648 \u0627\u0644\u0645\u0627\u0645\u0648\u062c\u0631\u0627\u0645 \u0625\u0630\u0627 \u0644\u0645 \u062a\u0648\u0641\u0631) \u0648\u0639\u0645\u0644 \u0645\u0633\u062d \u0639\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0628\u064a\u0636 \u0648\u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u062a\u0627.<\/p>\n

\u0627\u0644\u0648\u0642\u0627\u064a\u0629: \u0627\u0644\u062a\u062f\u062e\u0644 \u0627\u0644\u062c\u0631\u0627\u062d\u064a \u0627\u0644\u0648\u0642\u0627\u0626\u064a (\u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u062b\u062f\u064a\u064a\u0646 \u0648 \u0627\u0644\u0645\u0628\u064a\u0636\u064a\u0646) \u0648 \u0627\u0644\u062f\u0648\u0627\u0626\u064a ( \u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646) \u064a\u0642\u0644\u0644 \u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648 \u062d\u0628\u0648\u0628 \u0645\u0646\u0639 \u0627\u0644\u062d\u0645\u0644 \u062a\u0642\u0644\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0628\u064a\u0636\u064a\u0646 .\u0645\u0646 \u064a\u0631\u062b \u0646\u0633\u062e\u0629 \u0645\u0639\u0637\u0648\u0628\u0629 (\u0637\u0641\u0631\u0629) \u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u062c\u064a\u0646 \u0644\u062f\u064a\u0647 \u0627\u062d\u062a\u0645\u0627\u0644 \u064a\u0635\u0644 \u0627\u0644\u0649 50% \u0627\u0644\u0649 \u0627\u0646 \u064a\u0648\u0631\u062b\u0647 \u0644\u0630\u0631\u064a\u062a\u0647 \u0648 50% \u064a\u0631\u062b\u0648\u0646 \u0646\u0633\u062e\u0629 \u0633\u0644\u064a\u0645\u0629 \u0645\u0646\u0647 \u0644\u0630\u0644\u0643 \u064a\u0646\u0635\u062d \u0628\u0641\u062d\u0635 \u0627\u0644\u0639\u0627\u0626\u0644\u0629 \u0644\u0644\u0648\u0642\u0627\u064a\u0629.<\/p>\n

\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0625\u0636\u0627\u0641\u064a\u0629:<\/h3>\n

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\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629: \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648\u0627\u0644\u0645\u0628\u064a\u0636 \u0627\u0644\u0648\u0631\u0627\u062b\u064a
\n\u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a: BRCA1 ,BRCA2
\n\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u0648\u0631\u0627\u0645: \u0628\u0634\u0643\u0644 \u0639\u0627\u0644\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648\u0627\u0644\u0645\u0628\u064a\u0636. \u0628\u0634\u0643\u0644 \u0627\u0642\u0644 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0648\u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u062a\u0627 \u0648\u0627\u0644\u0631\u062d\u0645 \u0648\u0627\u0644\u0634\u0627\u0645\u0627\u062a \u0627\u0644\u062c\u0644\u062f\u064a\u0629. Werathah<\/td>\n<\/tr>\n
\u0623\u0648\u0631\u0627\u0645 \u0627\u062e\u0631\u0649<\/strong><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u062a\u0627<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0634\u0627\u0645\u0627\u062a<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0639\u062f\u0629<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u062d\u0645<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0628\u064a\u0636<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a<\/b><\/b><\/td>\n\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 <\/b><\/b><\/td>\n<\/tr>\n
\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u0628\u0631\u0648\u062a\u0648\u0646\u064a\u0648\u0645 \u0628\u0627\u0644\u0628\u0637\u0646<\/b><\/td>\n<\/td>\nx<\/td>\nx<\/td>\n<\/td>\n<\/td>\nx<\/td>\nx<\/td>\nx<\/td>\n\u0627\u0644\u0627\u0646\u0627\u062b<\/b><\/td>\n<\/tr>\n
x<\/td>\nx<\/td>\nx<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\nx<\/td>\n\u0627\u0644\u0630\u0643\u0648\u0631<\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/h4>\n

(\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a\u0646\u0634 ) \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u063a\u064a\u0631 \u0627\u0644\u0633\u0644\u064a\u0644\u0647 \u0627\u0644\u0648\u0631\u0627\u062b\u064a<\/span>
\n Lynch Syndrome (Hereditary non-polyposis colorectal cancer)<\/span><\/h1>\n

 <\/p>\n

\u0623\u0634\u0647\u0631 \u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u0628\u0628 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0647\u0648 \u0645\u0627 \u064a\u0639\u0631\u0641 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a\u0646\u0634 \u0628\u0627\u0633\u0645 \u0627\u0644\u0637\u0628\u064a\u0628 \u0627\u0644\u0630\u064a \u0627\u0643\u062a\u0634\u0641\u0647\u0627 . \u0648 \u064a\u0637\u0644\u0642 \u0639\u0644\u064a\u0647 \u0623\u064a\u0636\u0627 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u063a\u064a\u0631 \u0627\u0644\u0633\u0644\u064a\u0644\u0647 \u0627\u0644\u0648\u0631\u0627\u062b\u064a . \u0648 \u0627\u0644\u0633\u0644\u064a\u0644\u0647 (Polyp)\u0647\u064a \u0627\u0644\u0645\u0635\u0637\u0644\u062d \u0627\u0644\u0639\u0644\u0645\u064a \u0644\u0644\u0632\u0648\u0627\u0626\u062f \u0627\u0644\u0644\u062d\u0645\u064a\u0629 (\u062a\u0648\u0631\u0645\u0627\u062a \u062d\u0645\u064a\u062f\u0629) \u062a\u0638\u0647\u0631 \u0641\u064a \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648 \u0644\u0643\u0646 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a\u0646\u0634 \u0644\u0627 \u064a\u0635\u0627\u062d\u0628\u0647\u0627 \u0632\u0648\u0627\u0626\u062f \u0644\u062d\u0645\u064a\u0629 \u0643\u062b\u064a\u0631\u0629 \u0644\u0630\u0644\u0643 \u0633\u0645\u064a \u0628\u0646\u0648\u0639 \u0627\u0644\u063a\u064a\u0631 \u0627\u0644\u0633\u0644\u064a\u0644\u0647. \u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0633\u0628\u0628\u0647 \u0637\u0641\u0631\u0629 \u0641\u064a \u0648\u0627\u062d\u062f \u0645\u0646 \u062e\u0645\u0633 \u062c\u064a\u0646\u0627\u062a \u0645\u062e\u062a\u0644\u0641\u0629 ( (MLH1, MSH2, MSH6, PMS2 and EPCAM,) \u0648 \u0647\u064a \u062c\u064a\u0646\u0627\u062a \u0645\u0647\u0645\u0629 \u0644\u0625\u0635\u0644\u0627\u062d \u0627\u0644\u0623\u062e\u0637\u0627\u0621 \u0641\u064a \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u0646\u0633\u062e \u0627\u0644\u062e\u0627\u0637\u0626.\u0648\u0627\u0643\u062b\u0631\u0647\u0627 \u0634\u064a\u0648\u0639\u0627 \u0637\u0641\u0631\u0627\u062a \u0641\u064a \u062c\u064a\u0646 MLH1 \u0648 \u0641\u064a \u062c\u064a\u0646 . MSH2<\/p>\n

\u0627\u0644\u0634\u062e\u0635 \u0627\u0644\u0630\u064a \u064a\u0631\u062b \u0627\u062d\u062f \u0647\u0630\u0647 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0639\u0637\u0648\u0628 \u0644\u062f\u064a\u0647 \u0646\u0633\u0628\u0629 \u0627\u0639\u0644\u0649 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0642\u0628\u0644 \u0633\u0646 \u0627\u0644\u062e\u0645\u0633\u064a\u0646 \u0639\u0627\u0645 \u0645\u0646 \u0627\u0644\u0639\u0645\u0631( \u062a\u062a\u0631\u0627\u0648\u062d \u0628\u064a\u0646 \u0633\u0646 44 \u0648 61 \u0639\u0627\u0645 .. \u0643\u0630\u0644\u0643 \u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u0627\u062a\u064a \u064a\u0631\u062b\u0646 \u0627\u062d\u062f \u0647\u0630\u0647 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0639\u0637\u0648\u0628\u0629 \u0627\u0643\u062b\u0631 \u0639\u0631\u0636\u0647 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u062d\u0645 \u0648 \u0627\u0644\u0645\u0628\u064a\u0636 \u0648 \u0623\u064a\u0636\u0627 \u0647\u0646\u0627\u0643 \u0627\u062d\u062a\u0645\u0627\u0644 \u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0648\u0631\u0627\u0645 \u0623\u062e\u0631\u0649 \u0645\u062b\u0644 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0639\u062f\u0629 \u0648 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0648 \u0627\u0644\u0643\u0644\u0649 \u0648 \u0627\u0644\u062d\u0627\u0644\u0628 \u0648 \u0627\u0644\u0645\u062e \u0648 \u0627\u0644\u0643\u0628\u062f \u0648 \u0627\u0644\u0642\u0646\u0627\u0629 \u0627\u0644\u0635\u0641\u0631\u0627\u0648\u064a\u0629. \u0643\u0645\u0627 \u064a\u0637\u0644\u0642 \u0623\u064a\u0636\u0627 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0645\u064a\u0648\u0631 \u062a\u0648\u0631\u064a(Muir Torre Syndrome) \u0639\u0644\u0649 \u0645\u0646 \u064a\u0635\u0627\u0628 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648 \u0627\u0648\u0631\u0627\u0645 \u0641\u064a \u0627\u0644\u062c\u0644\u062f \u0648\u064a\u0637\u0644\u0642 \u0623\u064a\u0636\u0627 \u0627\u0633\u0645 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062a\u0648\u0631\u0643\u0648\u062a (Turcot Syndrome)\u0639\u0644\u0649 \u0645\u0646 \u0644\u062f\u064a\u0647 \u0633\u0631\u0637\u0627\u0646 \u0628\u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0645\u0639 \u0648\u0631\u0645 \u0628\u0627\u0644\u0645\u062e \u062e\u0627\u0635\u0629 \u0627\u0630\u0627 \u0648\u0631\u0645 \u064a\u0633\u0645\u0649 \u062c\u0644\u064a\u0648\u0628\u0644\u0633\u062a\u0648\u0645\u0627 (Glioblastoma).\u0627\u0644\u0645\u0628\u064a\u0636 \u062e\u0644\u0627\u0644 \u062d\u064a\u0627\u062a\u0647\u0646 \u0645\u0642\u0627\u0631\u0646\u0647 \u0628\u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u062a\u064a \u0644\u062f\u064a\u0647\u0646 \u0646\u0633\u062e\u0629 \u0633\u0644\u064a\u0645\u0629 .\u0643\u0645\u0627 \u0623\u0646 \u0627\u0644\u0631\u062c\u0627\u0644 \u0627\u0644\u0630\u064a\u0646 \u064a\u0631\u062b\u0648\u0646 \u0647\u0630\u0627 \u0627\u0644\u062c\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0646\u0633\u0628\u0629 \u0627\u0639\u0644\u0649 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648 \u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u062a\u0627 \u062e\u0644\u0627\u0644 \u062d\u064a\u0627\u062a\u0647\u0645 .\u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0627\u0644\u0649 \u0623\u0646 \u0628\u0639\u0636 \u0627\u0644\u0627\u0633\u0631 \u0644\u062f\u064a\u0647\u0645 \u0646\u0633\u0628\u0629 \u0627\u0639\u0644\u0649 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0648 \u0627\u0644\u0634\u0627\u0645\u0627\u062a \u0627\u0644\u062c\u0644\u062f\u064a\u0629 (\u0627\u0644\u0645\u064a\u0644\u0627\u0646\u0648\u0645\u0627).<\/p>\n

\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629: \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u063a\u064a\u0631 \u0627\u0644\u0633\u0644\u064a\u0644\u0647 \u0627\u0644\u0648\u0631\u0627\u062b\u064a (\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a\u0646\u0634)
\n\u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a: MLH1, MSH2, MSH6, PMS2 ,EPCAM
\n\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u0648\u0631\u0627\u0645: \u0628\u0634\u0643\u0644 \u0639\u0627\u0644\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 . \u0628\u0634\u0643\u0644 \u0627\u0642\u0644 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u062d\u0645 \u0648 \u0627\u0644\u0645\u0628\u064a\u0636\u060c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0639\u062f\u0629 \u0648 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0648 \u0627\u0644\u0643\u0644\u0649 \u0648 \u0627\u0644\u062d\u0627\u0644\u0628 \u0648 \u0627\u0644\u0645\u062e \u0648 \u0627\u0644\u0643\u0628\u062f \u0648 \u0627\u0644\u0642\u0646\u0627\u0629 \u0627\u0644\u0635\u0641\u0631\u0627\u0648\u064a\u0629 \u0648 \u0628\u0635\u064a\u0644\u0627\u062a \u0627\u0644\u0634\u0639\u0631 .<\/h3>\n

\u0646\u0633\u0628 \u0627\u0644\u0625\u0635\u0627\u0628\u0629:<\/h3>\n

\u0646\u0633\u0628\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0644\u0645\u0646 \u0644\u062f\u064a\u0647 \u0637\u0641\u0631\u0629 \u0641\u064a \u0627\u062d\u062f \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u062a\u062a\u0631\u0627\u0648\u062d \u0628\u064a\u0646 52% \u0627\u0644\u0649 82% \u062e\u0644\u0627\u0644 \u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u0639\u0645\u0644 \u0642\u0628\u0644 \u0633\u0646 70 \u0639\u0627\u0645. \u0648 \u0628\u0646\u0633\u0628\u0629 25% \u0627\u0644\u0649 60% \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u062d\u0645 \u0639\u0646\u062f \u0633\u0646 70 \u0639\u0627\u0645. \u0648 \u0627\u062d\u062a\u0645\u0627\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0645\u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u062e\u0644\u0644 \u0641\u064a \u062c\u064a\u0646 MSH6 \u0623\u0648 PMS2\u0627\u0642\u0644 \u0645\u0645\u0646 \u0644\u062f\u064a\u0647 \u062e\u0644\u0644 \u0641\u064a \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649.<\/p>\n

\u0627\u0644\u0646\u0635\u0627\u0626\u062d \u0627\u0644\u0627\u0631\u0634\u0627\u062f\u064a\u0629:<\/h3>\n

\u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u0637\u0641\u0631\u0629 \u0641\u064a \u0623\u062d\u062f \u0647\u0630\u0647 \u0627\u0644\u062c\u064a\u0646\u064a\u0646 \u064a\u0646\u0635\u062d \u0628\u0625\u062c\u0631\u0627\u0621 \u0645\u0646\u0638\u0627\u0631 \u0644\u0644\u0642\u0648\u0644\u0648\u0646 \u0628\u0634\u0643\u0644 \u062f\u0648\u0631\u064a \u0648 \u0643\u0630\u0644\u0643 \u0644\u0644\u0645\u0639\u062f\u0629 \u0644\u0648 \u0643\u0627\u0646 \u0645\u0635\u0627\u0628 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646. \u0643\u0630\u0644\u0643 \u0639\u0645\u0644 \u0645\u0633\u062d \u0639\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0628\u064a\u0636.<\/p>\n

\u0627\u0644\u0648\u0642\u0627\u064a\u0629:<\/h3>\n

\u0627\u0644\u062a\u062f\u062e\u0644 \u0627\u0644\u062c\u0631\u0627\u062d\u064a \u0627\u0644\u0648\u0642\u0627\u0626\u064a (\u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u0642\u0648\u0644\u0648\u0646) \u0648 \u0627\u0644\u062f\u0648\u0627\u0626\u064a ( \u0627\u0644\u0627\u0633\u0628\u0631\u064a\u0646) \u064a\u0642\u0644\u0644 \u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 .\u0645\u0646 \u064a\u0631\u062b \u0646\u0633\u062e\u0629 \u0645\u0639\u0637\u0648\u0628\u0629 (\u0637\u0641\u0631\u0629) \u0645\u0646 \u0627\u062d\u062f \u0647\u0630\u0647 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0644\u062f\u064a\u0647 \u0627\u062d\u062a\u0645\u0627\u0644 \u064a\u0635\u0644 \u0627\u0644\u0649 50% \u0644\u062a\u0648\u0631\u064a\u062b\u0647 \u0627\u0644\u0649 \u0627\u062d\u062f \u0627\u0641\u0631\u0627\u062f \u0630\u0631\u064a\u062a\u0647 \u0641\u064a \u0643\u0644 \u062d\u0645\u0644 \u0648 50% \u0627\u062d\u062a\u0645\u0627\u0644 \u0623\u0646 \u064a\u0631\u062b\u0648\u0627 \u0646\u0633\u062e\u0629 \u0633\u0644\u064a\u0645\u0629 \u0645\u0646\u0647 \u0644\u0630\u0644\u0643 \u064a\u0646\u0635\u062d \u0628\u0641\u062d\u0635 \u0627\u0644\u0639\u0627\u0626\u0644\u0629 \u0644\u0644\u0648\u0642\u0627\u064a\u0629.<\/p>\n

\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0625\u0636\u0627\u0641\u064a\u0629:<\/h3>\n

\u064a\u063a\u0644\u0628 \u0627\u0646 \u064a\u0643\u0648\u0646 \u0627\u0644\u0633\u0644\u0637\u0627\u0646 \u0641\u064a \u0627\u0644\u062c\u0632\u0621 \u0627\u0644\u0623\u064a\u0645\u0646 \u0645\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646. \u0628\u0639\u0636 \u0627\u0644\u0645\u062e\u062a\u0628\u0631\u0627\u062a \u062a\u0633\u062a\u062e\u062f\u0645 \u0635\u0628\u063a\u0627\u062a \u0628\u0623\u062c\u0633\u0627\u0645 \u0645\u0636\u0627\u062f\u0629 \u0636\u062f \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0647\u0630\u0647 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0644\u0643\u064a \u062a\u0639\u0631\u0641 \u0627\u0630\u0627 \u0645\u0627 \u0643\u0627\u0646 \u0641\u064a\u0647\u0627 \u062e\u0644\u0644 \u0627\u0645 \u0644\u0627 .\u0643\u0645\u0627 \u0623\u064a\u0636\u0627 \u064a\u0639\u0645\u0644 \u0641\u062d\u0635 \u0639\u062f\u0645 \u0627\u0633\u062a\u0642\u0631\u0627\u0631 \u0627\u0644\u0645\u064a\u0643\u0631\u0648 \u0633\u062a\u0627\u0644\u064a\u062a (Microsatellite instability (MSI) \u062d\u064a\u062b \u064a\u0634\u064a\u0639 \u0627\u0646 \u064a\u0638\u0647\u0631 \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u0627\u0631\u062a\u0641\u0627\u0639 \u0641\u064a \u0645\u0639\u062f\u0644\u0627\u062a\u0647\u0627 .\u0639\u0644\u0645\u0627 \u0623\u0646 15% \u0645\u0646 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0638\u0647\u0631 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u062d\u0644\u064a\u0644 \u063a\u064a\u0631 \u0637\u0628\u064a\u0639\u064a\u0629 \u064a\u0643\u0648\u0646 \u0645\u0646 \u0646\u0648\u0639 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u063a\u064a\u0631 \u0648\u0631\u0627\u062b\u064a.<\/p>\n\n\n\n\n\n\n
\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629: \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u063a\u064a\u0631 \u0627\u0644\u0633\u0644\u064a\u0644\u0647 \u0627\u0644\u0648\u0631\u0627\u062b\u064a (\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a\u0646\u0634)
\n\u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a: MSH2, MLH1, MSH6, PMS2, EPCAM
\n\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u0648\u0631\u0627\u0645: \u0628\u0634\u0643\u0644 \u0639\u0627\u0644\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646. \u0628\u0634\u0643\u0644 \u0627\u0642\u0644 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0627\u0644\u0631\u062d\u0645 \u0648 \u0627\u0644\u0645\u0628\u064a\u0636 \u0648 \u0627\u0644\u0645\u0639\u062f\u0629 \u0648 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0648 \u0627\u0644\u0645\u062e \u0648 \u0627\u0644\u0643\u0644\u0649 \u0648 \u0627\u0644\u062d\u0627\u0644\u0628 \u0648 \u0627\u0644\u0643\u0628\u062f \u0648 \u0642\u0646\u0627\u0629 \u0627\u0644\u0635\u0641\u0631\u0627\u0648\u064a\u0629 \u0648 \u0628\u0635\u064a\u0644\u0627\u062a \u0627\u0644\u0634\u0639\u0631 . Werathah<\/td>\n<\/tr>\n
\u0623\u0648\u0631\u0627\u0645 \u0627\u062e\u0631\u0649<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0643\u0628\u062f \u0648 \u0627\u0644\u0642\u0646\u0627\u0629 \u0627\u0644\u0635\u0641\u0631\u0627\u0648\u064a\u0629<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0643\u0644\u0649<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0639\u062f\u0629<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u062d\u0645<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0628\u064a\u0636<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a<\/b><\/b><\/td>\n\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 <\/b><\/b><\/td>\n<\/tr>\n
\u0633\u0631\u0637\u0627\u0646 \u0628\u0635\u064a\u0644\u0627\u062a \u0627\u0644\u0634\u0639\u0631 \u0648 \u0627\u0644\u0645\u062e <\/b><\/td>\nx<\/td>\nxx<\/td>\nx<\/td>\nx<\/td>\nX<\/td>\nx<\/td>\nx<\/td>\n<\/td>\n\u0627\u0644\u0627\u0646\u0627\u062b<\/b><\/td>\n<\/tr>\n
x<\/td>\n<\/td>\nx<\/td>\nx<\/td>\nx<\/td>\n<\/td>\n<\/td>\n<\/td>\n\u0627\u0644\u0630\u0643\u0648\u0631<\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062a\u0648\u0631\u0645\u0627\u062a \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0645\u062a\u0639\u062f\u062f\u0629<\/span>
\n Syndrome Multiple Endocrine Neoplasia<\/span><\/h1>\n

\u0645\u0646 \u0623\u0634\u0647\u0631 \u0645\u062a\u0644\u0627\u0632\u0645\u0627\u062a \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u062a\u064a \u062a\u0635\u064a\u0628 \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0635\u0645\u0627\u0621\u060c \u0648 \u064a\u0635\u064a\u0628 \u062d\u0648\u0627\u0644\u064a \u0648\u0627\u062d\u062f \u0645\u0646 \u0643\u0644 30 \u0627\u0644\u0641 \u0646\u0633\u0645\u0629 . \u0648\u0647\u0646\u0627\u0643 \u0646\u0648\u0639\u0627\u0646 \u0645\u0646\u0647. \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0623\u0648\u0644 \u064a\u0633\u0628\u0628 \u062a\u0648\u0631\u0645\u0627\u062a (\u0641\u064a \u0627\u0644\u0639\u0627\u062f\u0629 \u062d\u0645\u064a\u062f\u0629) \u0641\u064a \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0648\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062c\u0627\u0631 \u062f\u0631\u0642\u064a\u0629 \u0641\u064a \u0627\u0644\u0631\u0642\u0628\u0629 \u0648\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0646\u062e\u0627\u0645\u064a\u0629 \u0641\u064a \u0627\u0644\u0645\u062e. \u0648\u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u064a\u0633\u0628\u0628 \u062a\u0648\u0631\u0645\u0627\u062a \u0641\u064a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0648\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629. \u0645\u0639 \u0627\u0646\u0647 \u0648\u0631\u0627\u062b\u064a \u0627\u0644\u0627 \u0627\u0646 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0628 \u0645\u0646\u0647 \u0641\u064a \u0627\u0644\u063a\u0627\u0644\u0628 \u0644\u0627 \u064a\u0648\u062c\u062f \u0623\u062d\u062f \u0645\u0635\u0627\u0628 \u0641\u064a \u0627\u0644\u0627\u0633\u0631\u0629\u060c \u0628\u064a\u0646\u0645\u0627 \u0627\u0644\u0646\u0648\u0639 \u0623 \u064a\u0643\u0648\u0646 \u0647\u0646\u0627\u0643 \u062a\u0627\u0631\u064a\u062e \u0639\u0627\u0626\u0644\u064a \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0641\u064a \u0627\u062d\u062f \u0627\u0641\u0631\u0627\u062f \u0627\u0644\u0627\u0633\u0631\u0629.<\/p>\n

\u064a\u062d\u062f\u062b \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0623\u0648\u0644 \u0628\u0633\u0628\u0628 \u0637\u0641\u0631\u0629 \u0641\u064a \u062c\u064a\u0646 \u0627\u0633\u0645\u0647 (MEN1). \u062d\u064a\u062b \u0644\u0627 \u064a\u0639\u0631\u0641 \u0628\u0627\u0644\u0636\u0628\u0637 \u0637\u0631\u064a\u0642\u0629 \u0639\u0645\u0644 \u0647\u0630\u0627 \u0627\u0644\u062c\u064a\u0646. \u0623\u0645\u0627 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0641\u064a\u062d\u062f\u062b \u0628\u0633\u0628\u0628 \u062e\u0644\u0644 \u0641\u064a \u062c\u064a\u0646 \u0627\u0633\u0645\u0647 (RET) \u0648 \u0627\u0644\u0630\u064a \u064a\u062a\u062d\u0643\u0645 \u0641\u064a \u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627\u060c \u062d\u064a\u062b \u062a\u062a\u0643\u0627\u062b\u0631 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0628\u0632\u064a\u0627\u062f\u0629 \u0639\u0646\u062f \u062d\u062f\u0648\u062b \u0637\u0641\u0631\u0629 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u062c\u064a\u0646. \u0648 \u064a\u062a\u0645 \u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u0637\u0641\u0631\u0629 \u0641\u064a 10 \u0627\u0644\u0649 35% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0647\u0630\u0647 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0648 \u0647\u0648 \u064a\u0646\u062a\u0642\u0644 \u0628\u0627\u0644\u0648\u0631\u0627\u062b\u0629 \u0627\u0644\u0633\u0627\u0626\u062f\u0629. \u0645\u0639 \u0623\u0646 \u0645\u0639\u0638\u0645 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u062a\u0643\u0648\u0646 \u0628\u0633\u0628\u0628 \u0637\u0641\u0631\u0629 \u062c\u062f\u064a\u062f\u0629 \u0644\u064a\u0633\u062a \u0645\u0648\u062c\u0648\u062f\u0647 \u0639\u0646 \u0627\u0644\u0648\u0627\u0644\u062f\u064a\u0646 \u0643\u0645\u0627 \u0630\u0643\u0631\u0646\u0627 \u0633\u0627\u0628\u0642\u0627\u064b.<\/p>\n

\u064a\u062d\u062f\u062b \u0628\u0633\u0628\u0628 \u062e\u0644\u0644 \u0641\u064a \u062c\u064a\u0646 \u0627\u0633\u0645\u0647 \u0623\u0645 \u0627\u064a \u0623\u0646 \u0648\u0627\u062d\u062f (MEN1). \u0623\u0645\u0627 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0641\u064a\u062d\u062f\u062b \u0628\u0633\u0628\u0628 \u062e\u0644\u0644 \u0641\u064a \u062c\u064a\u0646 \u0627\u0633\u0645\u0647 \u0631\u064a\u062a (RET).<\/p>\n

\u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0623\u0648\u0644:<\/span><\/h3>\n

– \u0645\u0639\u0638\u0645 \u0627\u0644\u062a\u0648\u0631\u0645\u0627\u062a \u062d\u0645\u064a\u062f\u0629 (\u063a\u064a\u0631 \u0633\u0631\u0637\u0627\u0646\u064a\u0629 ) \u0648 \u0644\u0643\u0646 \u062b\u0644\u062b \u0623\u0646\u0648\u0627\u0639 \u0627\u0648\u0631\u0627\u0645 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0627\u0648 \u0627\u0644\u0635\u062f\u0631 \u0642\u062f \u062a\u0643\u0648\u0646 \u0633\u0631\u0637\u0627\u0646\u064a\u0629.<\/p>\n

– \u062a\u062d\u062f\u062b \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0641\u064a \u0627\u0644\u0639\u0627\u062f\u0629 \u062e\u0644\u0627\u0644 \u0627\u0644\u062e\u0645\u0633\u064a\u0646 \u0633\u0646\u0647 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u0627\u0644\u0639\u0645\u0631<\/p>\n

– \u064a\u0633\u0628\u0628 \u0627\u0631\u062a\u0641\u0627\u0639 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062c\u0627\u0631 \u062f\u0631\u0642\u064a\u0629 \u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0648\u0645 \u0641\u064a \u0627\u0644\u062f\u0645.<\/p>\n

– \u0627\u063a\u0644\u0628 \u0627\u0644\u0627\u0639\u0631\u0627\u0636 \u0647\u0648 \u0628\u0633\u0628\u0628 \u0632\u064a\u0627\u062f\u0629 \u0627\u0641\u0631\u0627\u0632 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0645\u062b\u0644 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u062d\u0644\u064a\u0628 \u062d\u064a\u062b \u064a\u062f\u0631 \u0627\u0644\u062d\u0644\u064a\u0628 \u0645\u0646 \u0627\u0644\u062b\u062f\u064a \u0648 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0646\u0645\u0648 ( \u0643\u0644\u0627\u0647\u0645\u0627 \u0645\u0646 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0646\u062e\u0627\u0645\u064a\u0629 ) \u0648 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0643\u0648\u0631\u062a\u064a\u0632\u0648\u0646 ( \u0645\u0646 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629) \u0648 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u062c\u0627\u0633\u062a\u0631\u064a\u0646 ( \u0645\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 ) \u064a\u0639\u0631\u0641 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0632\u0648\u0644\u064a\u0646\u062c\u0631 \u0627\u0644\u064a\u0633\u0648\u0646 ()\u0641\u062a\u0633\u0628\u0628 \u062a\u0642\u0631\u062d\u0627\u062a \u0645\u062a\u0639\u062f\u062f\u0629 \u0641\u064a \u0627\u0644\u0645\u0639\u062f\u062960% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 . \u0648\u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u062c\u0644\u0648\u0643\u0627\u062c\u0648\u0646 \u0648\u0627\u0644\u0630\u064a \u064a\u0631\u0641\u0639 \u0627\u0644\u0633\u0643\u0631 \u0641\u064a \u0627\u0644\u062f\u0645 \u0648 \u0623\u064a\u0636\u0627 \u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648 \u0627\u0644\u062a\u064a \u062a\u0633\u0628\u0628 \u0627\u0633\u0647\u0627\u0644.<\/p>\n

– \u0642\u062f \u064a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0623\u0639\u0636\u0627\u0621 \u0623\u062e\u0631\u0649 \u063a\u064a\u0631 \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0635\u0645\u0627\u0621: \u0641\u0642\u062f \u064a\u0633\u0628\u0628 \u062a\u0648\u0631\u0645\u0627\u062a \u0644\u064a\u0641\u064a\u0647 \u062f\u0645\u0648\u064a\u0629 \u0641\u064a \u0627\u0644\u0648\u062c\u0647 \u0648 \u0628\u0639\u0636 \u0627\u0644\u0632\u0648\u0627\u0626\u062f \u0627\u0644\u0644\u062d\u0645\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u062c\u0644\u062f \u0648 \u062a\u0648\u0631\u0645\u0627\u062a \u062f\u0647\u0646\u064a\u0629 \u0648 \u0639\u0636\u0644\u064a\u0629 \u0648 \u0623\u062d\u064a\u0627\u0646\u0627 \u062a\u0648\u0631\u0645\u0627\u062a \u0641\u064a \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u0645\u063a\u0637\u064a (meningiomas) \u0623\u0648 \u0627\u0644\u0645\u0628\u0637\u0646 \u0644\u0644\u0645\u062e (ependymomas) .<\/p>\n

– \u0645\u0639\u0638\u0645 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u062a\u0627\u0631\u064a\u062e \u0639\u0627\u0626\u0644\u064a \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0647\u0630\u0627 \u0644\u0645\u0631\u0636 \u0639\u0644\u0645\u0627\u064b \u0623\u0646 10% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0647\u0645 \u0627\u0648\u0644 \u0641\u0631\u062f \u0641\u064a \u0627\u0644\u0627\u0633\u0631\u0629 \u064a\u0635\u0627\u0628.<\/p>\n

– \u0627\u0644\u0645\u0631\u0636 \u064a\u0646\u062a\u0642\u0644 \u0628\u0627\u0644\u0648\u0631\u0627\u062b\u0629 \u0627\u0644\u0633\u0627\u0626\u062f\u0629 \u060c \u0623\u064a \u0623\u0646 \u0627\u0644\u0645\u0635\u0627\u0628 \u0644\u062f\u064a\u0647 50% \u0627\u0646 \u064a\u0646\u0642\u0644 \u0647\u0630\u0627 \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0639\u0637\u0648\u0628 \u0627\u0644\u0649 \u0630\u0631\u064a\u062a\u0647 \u0643\u0645\u0627 \u0623\u0646 50% \u0645\u0646 \u0630\u0631\u064a\u062a\u0647 \u062a\u0643\u0648\u0646 \u0633\u0644\u064a\u0645\u0647 \u0648 \u0647\u0630\u0647 \u0627\u0644\u0646\u0633\u0628\u0629 \u062b\u0627\u0628\u062a\u0647 \u0641\u064a \u0643\u0644 \u062d\u0645\u0644.<\/p>\n

– \u0628\u0627\u0644\u0625\u0645\u0643\u0627\u0646 \u062a\u0641\u0627\u062f\u064a \u0625\u0635\u0627\u0628\u0629 \u0627\u0644\u0630\u0631\u064a\u0629 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u062c\u0631\u0627\u0621 \u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u0648\u0631\u0627\u062b\u064a \u0642\u0628\u0644 \u0627\u0644\u063a\u0631\u0632.(\u0631\u0627\u062c\u0639 \u0627\u0644\u0634\u0631\u062d \u0639\u0646\u0647\u0627 \u0641\u064a \u0645\u0648\u0642\u0639 \u0648\u0631\u0627\u062b\u0629).<\/p>\n

– \u064a\u0633\u062a\u062f\u0639\u064a \u0627\u0644\u0627\u0645\u0631 \u0639\u0645\u0644 \u062c\u0631\u0627\u062d\u0629 \u0627\u062d\u062a\u0631\u0627\u0632\u064a\u0629 \u0648\u0642\u0627\u0626\u064a\u0629 \u0628\u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u062e\u0644\u0627\u0644 \u0627\u0644\u0633\u062a \u0633\u0646\u0648\u0627\u062a \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u0644\u0639\u0645\u0631 \u0644\u062a\u0641\u0627\u062f\u064a \u062d\u062f\u0648\u062b \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0644\u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0623\u060c \u0648\u062e\u0644\u0627\u0644 \u062b\u0644\u0627\u062b \u0633\u0646\u0648\u0627\u062a \u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0628 \u0648\u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a.<\/p>\n

– \u064a\u0648\u0635\u0649 \u0628\u0642\u064a\u0627\u0633 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0648\u0645 \u0633\u0646\u0648\u064a\u0627 \u0645\u0646\u0630 \u0633\u0646 \u0627\u0644\u062b\u0627\u0645\u0646\u0629 \u0645\u0646 \u0627\u0644\u0639\u0645\u0631 .<\/p>\n

– \u064a\u0648\u0635\u0649 \u0628\u0642\u064a\u0627\u0633 \u0645\u0633\u062a\u0648\u0649 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u062d\u0644\u064a\u0628 (prolactin) \u0648 \u0627\u0644\u0627\u0646\u0633\u0648\u0644\u064a\u0646 \u0648 \u0623\u064a\u0636\u0627 (IGF-1) \u0639\u0646\u062f \u0633\u0646 \u0627\u0644\u062e\u0627\u0645\u0633\u0629 \u0623\u0648 \u0627\u0644\u0639\u0627\u0634\u0631\u0629 \u0645\u0646 \u0627\u0644\u0639\u0645\u0631. \u0648\u064a\u0639\u0627\u062f \u0643\u0644 \u0633\u0646\u0647 \u0627\u0648 \u062b\u0644\u0627\u062b \u0633\u0646\u0648\u0627\u062a.<\/p>\n

– \u064a\u0648\u0635\u0649 \u0628\u0639\u0645\u0644 \u0627\u0634\u0639\u0629 \u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a\u0629 \u0644\u0644\u0645\u062e \u0645\u0644 \u062b\u0644\u0627\u062b \u0623\u0648 \u062e\u0645\u0633 \u0633\u0646\u0648\u0627\u062a \u0639\u0646\u062f \u0633\u0646 \u0627\u0644\u062e\u0627\u0645\u0633\u0629 \u0627\u0648 \u0627\u0644\u0639\u0627\u0634\u0631\u0629 \u0645\u0646 \u0627\u0644\u0639\u0645\u0631 \u0627\u0648 \u0639\u0646\u062f \u0627\u0631\u062a\u0641\u0627\u0639 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u062d\u0644\u064a\u0628 \u0627\u0648 IGF-1.<\/p>\n

– \u064a\u0648\u0635\u0649 \u0628\u0639\u0645\u0644 \u0627\u0634\u0639\u0629 \u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a\u0629 \u0623, \u0645\u0642\u0637\u0639\u064a\u0629 \u0644\u0644\u0628\u0637\u0646 \u0648 \u0627\u0644\u0635\u062f\u0631 \u0643\u0644 2 \u0627\u0644\u0649 4 \u0633\u0646\u0648\u0627\u062a \u0639\u0646\u062f \u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u0644\u062c\u0627\u0633\u062a\u0631\u064a\u0646 \u0623\u0648 \u0639\u0646\u062f \u0633\u0646 \u0627\u0644\u0639\u0634\u0631\u064a\u0646 \u0645\u0646 \u0627\u0644\u0639\u0645\u0631. \u0639\u0644\u0645\u0627 \u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u062a\u0648\u0635\u064a\u0627\u062a \u062a\u0631\u0627\u062c\u0639 \u0628\u064a\u0646 \u0641\u062a\u0631\u0629 \u0648\u0623\u062e\u0631\u0649.<\/p>\n\n\n\n\n\n\n
\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629: \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062a\u0648\u0631\u0645\u0627\u062a \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0623\u0648\u0644<\/p>\n

\u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a: MEN1
\n\u064a\u0633\u0628\u0628 \u062a\u0648\u0631\u0645\u0627\u062a (\u0641\u064a \u0627\u0644\u0639\u0627\u062f\u0629 \u062d\u0645\u064a\u062f\u0629) \u0641\u064a \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0648\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062c\u0627\u0631 \u062f\u0631\u0642\u064a\u0629 \u0641\u064a \u0627\u0644\u0631\u0642\u0628\u0629 \u0648\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0646\u062e\u0627\u0645\u064a\u0629 \u0641\u064a \u0627\u0644\u0645\u062e \u0648 \u0623\u064a\u0636\u0627 \u064a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0623\u0639\u0636\u0627\u0621 \u063a\u064a\u0631 \u0627\u0644\u063a\u062f\u062f . Werathah<\/td>\n<\/tr>\n

\u0623\u0648\u0631\u0627\u0645 \u0627\u062e\u0631\u0649<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u062e<\/b><\/td>\n\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0646\u062e\u0627\u0645\u064a\u0629<\/b><\/td>\n\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629<\/b><\/b><\/td>\n\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629<\/b><\/td>\n\u0623\u0648\u0627\u0645<\/b><\/p>\n

\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062c\u0627\u0631 \u062f\u0631\u0642\u064a\u0629<\/b><\/b><\/td>\n

\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629<\/b><\/b><\/td>\n<\/td>\n<\/tr>\n
\u064a\u0633\u0628\u0628 \u062a\u0648\u0631\u0645\u0627\u062a \u0644\u064a\u0641\u064a\u0647 \u062f\u0645\u0648\u064a\u0629 \u0641\u064a \u0627\u0644\u0648\u062c\u0647 \u0648 \u0628\u0639\u0636 \u0627\u0644\u0632\u0648\u0627\u0626\u062f \u0627\u0644\u0644\u062d\u0645\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u062c\u0644\u062f \u0648 \u062a\u0648\u0631\u0645\u0627\u062a \u062f\u0647\u0646\u064a\u0629 \u0648 \u0639\u0636\u0644\u064a\u0629 \u0648 \u0623\u062d\u064a\u0627\u0646\u0627 \u062a\u0648\u0631\u0645\u0627\u062a \u0641\u064a \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u0645\u063a\u0637\u064a \u0623\u0648 \u0627\u0644\u0645\u0628\u0637\u0646 \u0644\u0644\u0645\u062e.<\/b><\/td>\nX<\/td>\nX<\/td>\nX<\/td>\nx<\/td>\n<\/td>\nx<\/td>\n\u0627\u0644\u0627\u0646\u0627\u062b<\/b><\/td>\n<\/td>\n<\/tr>\n
x<\/td>\nx<\/td>\nx<\/td>\nx<\/td>\n<\/td>\nx<\/td>\n\u0627\u0644\u0630\u0643\u0648\u0631<\/b><\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

– \u0627\u0644\u0639\u0644\u0627\u062c \u0647\u0648 \u0628\u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0647\u0630\u0647 \u0627\u0644\u062a\u0648\u0631\u0645\u0627\u062a \u0639\u0646\u062f \u062d\u062f\u0648\u062b \u0645\u0636\u0627\u0639\u0641\u0627\u062a \u0644\u0627 \u064a\u0645\u0643\u0646 \u0627\u0644\u0633\u064a\u0637\u0631\u0629 \u0639\u0644\u064a\u0647\u0627 \u0645\u062b\u0644 \u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0648\u0645 \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631 \u0627\u0648 \u0645\u0634\u0627\u0643\u0644 \u0641\u064a \u0627\u0644\u0643\u0644\u0649 \u0628\u0633\u0628\u0628 \u0627\u0644\u062d\u0635\u0648\u0627\u062a \u0627\u0648 \u0628\u0633\u0628\u0628 \u0645\u0634\u0627\u0643\u0644 \u0641\u064a \u0627\u0648\u0631\u0627\u0645 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0627\u0648 \u0641\u064a \u0627\u0644\u0643\u0648\u0631\u062a\u064a\u0632\u0648\u0646 \u0645\u0646 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629. \u0628\u064a\u0646\u0645\u0627 \u0627\u0648\u0631\u0627\u0645 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0646\u062e\u0627\u0645\u064a\u0629 \u062a\u0639\u0627\u0644\u062c \u0628\u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u062f\u0648\u0628\u0627\u0645\u064a\u0646 \u0627\u0648 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0646\u0645\u0648.<\/p>\n

\u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a :<\/span><\/h3>\n

– \u064a\u0635\u064a\u0628 \u0634\u062e\u0635 \u0645\u0646 \u0643\u0644 30 \u0627\u0644\u0641 \u0646\u0633\u0645\u0629.<\/p>\n

– \u0627\u0644\u0648\u0631\u0645 \u0641\u064a \u0627\u0644\u063a\u0627\u0644\u0628 \u0648\u0631\u0645 \u0641\u064a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 ( \u0641\u064a \u0644\u0628 \u0627\u0644\u063a\u062f\u0629 medullary ) \u0648 \u064a\u0635\u064a\u0628 100% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636.<\/p>\n

– \u0648 \u0648\u0631\u0645 \u0641\u064a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629 \u0648 \u0628\u0642\u064a\u0629 \u0634\u0628\u0643\u0629 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0633\u0645\u0628\u062b\u0627\u0648\u064a<\/p>\n

– \u0648 \u0641\u0631\u0637 \u0641\u064a \u0639\u0645\u0644 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062c\u0627\u0631 \u062f\u0631\u0642\u064a\u0629 \u0646\u062a\u064a\u062c\u0629 \u0644\u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u063a\u062f\u0629.<\/p>\n

– \u0643\u0645\u0627 \u0642\u062f \u062a\u0638\u0647\u0631 \u0628\u0639\u0636 \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0639\u0644\u0649 \u0627\u0644\u062c\u0644\u062f \u062a\u0633\u0645\u0649 \u0628\u0627\u0644\u0625\u0646\u062c\u0644\u064a\u0632\u064a (lichen amyloidosis).<\/p>\n

– \u0643\u0645\u0627 \u0642\u062f \u064a\u0635\u0627\u0628 \u0628\u0639\u0636 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0628\u0645\u0634\u0643\u0644\u0629 \u0641\u064a \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u062a\u0633\u0645\u0649 \u0628\u0645\u0631\u0636 \u0647\u064a\u0631\u0634\u0628\u0631\u0646\u0642 (Hirschsprung) \u062d\u064a\u062b \u064a\u0641\u062a\u0642\u062f \u062c\u0632\u0621 \u0645\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0641\u064a \u062c\u062f\u0627\u0631\u0647 \u0641\u064a\u0633\u0628\u0628 \u0627\u0645\u0633\u0627\u0643 \u0634\u062f\u064a\u062f \u0628\u0633\u0628\u0628 \u0639\u062f\u0645 \u062a\u0648\u0633\u0639 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0639\u0646\u062f \u0645\u0631\u0648\u0631 \u0627\u0644\u0641\u0636\u0644\u0627\u062a.<\/p>\n

– \u064a\u0633\u062a\u062f\u0639\u064a \u0627\u0644\u0627\u0645\u0631 \u0639\u0645\u0644 \u062c\u0631\u0627\u062d\u0629 \u0627\u062d\u062a\u0631\u0627\u0632\u064a\u0629 \u0648\u0642\u0627\u0626\u064a\u0629 \u0628\u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u062e\u0644\u0627\u0644 \u0627\u0644\u0633\u062a \u0633\u0646\u0648\u0627\u062a \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u0644\u0639\u0645\u0631 \u0644\u062a\u0641\u0627\u062f\u064a \u062d\u062f\u0648\u062b \u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0644\u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0623\u060c \u0648\u062e\u0644\u0627\u0644 \u062b\u0644\u0627\u062b \u0633\u0646\u0648\u0627\u062a \u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0628 \u0648\u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a.<\/p>\n

– \u064a\u0648\u0635\u0649 \u0628\u0642\u064a\u0627\u0633 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0643\u0627\u0644\u0633\u064a\u0648\u0645 \u0648 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062c\u0627\u0631 \u062f\u0631\u0642\u064a\u0629 \u0633\u0646\u0648\u064a\u0627 \u0645\u0646\u0630 \u0627\u0644\u0637\u0641\u0648\u0644\u0629 \u0644\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0623.<\/p>\n

– \u064a\u0648\u0635\u0649 \u0628\u0642\u064a\u0627\u0633 \u0645\u0633\u062a\u0648\u0649 \u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629 ( \u0645\u064a\u062a\u0627\u0646\u0641\u0631\u064a\u0646 \u0648 \u0627\u0644\u0646\u0648\u0631\u0645\u064a\u062a\u0627\u0646\u0641\u0631\u064a\u0646 ) \u0648 \u0645\u0646\u062a\u062c\u0627\u062a\u0647\u0627 \u0627\u0644\u0633\u0645\u0628\u062b\u0627\u0648\u064a\u0629 \u0645\u0646\u0630 \u0627\u0644\u0637\u0641\u0648\u0644\u0629 \u0644\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0623 \u0648 \u0628 .<\/p>\n

– \u064a\u0648\u0635\u0649 \u0628\u0639\u0645\u0644 \u0627\u0634\u0639\u0629 \u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a\u0629 \u0627\u0648 \u0645\u0642\u0637\u0639\u064a\u0629 \u0644\u0644\u0628\u0637\u0646 \u0644\u0643\u0634\u0641 \u0639\u0646 \u062a\u0648\u0631\u0645\u0627\u062a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0633\u0645\u0628\u062b\u0627\u0648\u064a \u0643\u0644 4 \u0627\u0644\u0649 5 \u0633\u0646\u0648\u0627\u062a \u0639\u0646\u062f \u0627\u0631\u062a\u0641\u0627\u0639 \u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629 \u0648 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0633\u0645\u0628\u062b\u0627\u0648\u064a. \u0639\u0644\u0645\u0627 \u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u062a\u0648\u0635\u064a\u0627\u062a \u062a\u0631\u0627\u062c\u0639 \u0628\u064a\u0646 \u0641\u062a\u0631\u0629 \u0648\u0623\u062e\u0631\u0649.<\/p>\n

– \u0647\u0646\u0627\u0643 \u0627\u062f\u0648\u064a\u0629 \u062d\u062f\u064a\u062b\u0629 \u062a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u0627\u0644\u0627\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u0648\u0631\u0645 \u0641\u064a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0628\u0633\u0628\u0628 \u0637\u0641\u0631\u0629 \u0641\u064a \u062c\u064a\u0646 (\u0631\u064a\u062a) \u064a\u0633\u062a\u0639\u0645\u0644 \u0644\u0645\u0646 \u0627\u0646\u062a\u0634\u0631 \u0627\u0644\u0648\u0631\u0645 \u0644\u062f\u064a\u0647\u0645 \u0627\u0644\u0649 \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0644\u0645\u0641\u0627\u0648\u064a\u0629 \u0645\u062b\u0644 \u062f\u0648\u0627\u0621 \u0641\u0627\u0646\u062f\u064a\u062a\u0627\u0646\u064a\u0628 (vandetanib) \u0648 \u062f\u0648\u0627\u0621 \u0643\u0627\u0628\u0648\u0632\u0627\u0646\u062a\u064a\u0646\u064a\u0628 (cabozantinib) .<\/p>\n

\u0648\u064a\u0646\u0642\u0633\u0645 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0627\u0644\u0649 \u062b\u0644\u0627\u062b\u0629 \u0627\u0642\u0633\u0627\u0645:<\/p>\n

\u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0645\u0646 \u0641\u0626\u0629 (\u0623) :<\/span><\/strong><\/p>\n

– \u064a\u0645\u062b\u0644 60 \u0627\u0644\u0649 90% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a<\/p>\n

– \u062a\u062d\u062f\u062b \u062a\u0648\u0631\u0645\u0627\u062a \u0628\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 ( \u0641\u064a 98% to 100% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 )<\/p>\n

– \u0648 \u062a\u0648\u0631\u0645\u0627\u062a \u062d\u0645\u064a\u062f\u0629 \u0641\u064a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062c\u0627\u0631 \u062f\u0631\u0642\u064a\u0629 ( \u0641\u064a 5% to 10% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 )<\/p>\n

– \u0648 \u062a\u0648\u0631\u0645\u0627\u062a \u0628\u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0633\u0645\u0628\u062b\u0627\u0648\u064a ( \u0641\u064a 50% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 ) .<\/p>\n

– \u062a\u062d\u062f\u062b \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0628\u0628 \u0637\u0641\u0631\u0627\u062a \u0645\u0645\u064a\u0632\u0629 \u0641\u064a \u0627\u0644\u062c\u064a\u0646 (\u0631\u064a\u062a\u0632) \u0648 \u0641\u064a \u0627\u0644\u063a\u0627\u0644\u0628 \u0628\u0633\u0628\u0628 \u0637\u0641\u0631\u0629 \u0645\u0648\u0631\u0648\u062b\u0647 \u0645\u0646 \u0623\u062d\u062f \u0627\u0644\u0627\u0628\u0648\u064a\u0646 .<\/p>\n\n\n\n\n\n\n
\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629: \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062a\u0648\u0631\u0645\u0627\u062a \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0623<\/p>\n

\u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a: RET
\n\u064a\u0633\u0628\u0628 \u062a\u0648\u0631\u0645\u0627\u062a \u0641\u064a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0648\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062c\u0627\u0631 \u062f\u0631\u0642\u064a\u0629 \u0641\u064a \u0627\u0644\u0631\u0642\u0628\u0629 \u0648\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629 \u0648 \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0633\u0645\u0628\u062b\u0627\u0648\u064a Werathah<\/td>\n<\/tr>\n

\u0623\u0648\u0631\u0627\u0645 \u0627\u062e\u0631\u0649<\/b><\/td>\n\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629<\/b><\/td>\n\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629<\/b><\/b><\/td>\n\u0623\u0648\u0631\u0627\u0645 \u0641\u064a \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633<\/b><\/td>\n\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0646\u062e\u0627\u0645\u0629<\/b><\/td>\n\u0623\u0648\u0627\u0645<\/b><\/p>\n

\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062c\u0627\u0631 \u062f\u0631\u0642\u064a\u0629<\/b><\/b><\/td>\n

\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629<\/b><\/b><\/td>\n<\/td>\n<\/tr>\n
\u064a\u0633\u0628\u0628 \u062a\u0648\u0631\u0645\u0627\u062a \u0644\u064a\u0641\u064a\u0647 \u062f\u0645\u0648\u064a\u0629 \u0641\u064a \u0627\u0644\u0648\u062c\u0647 \u0648 \u0628\u0639\u0636 \u0627\u0644\u0632\u0648\u0627\u0626\u062f \u0627\u0644\u0644\u062d\u0645\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u062c\u0644\u062f \u0648 \u062a\u0648\u0631\u0645\u0627\u062a \u062f\u0647\u0646\u064a\u0629 \u0648 \u0639\u0636\u0644\u064a\u0629 \u0648 \u0623\u062d\u064a\u0627\u0646\u0627 \u062a\u0648\u0631\u0645\u0627\u062a \u0641\u064a \u0627\u0644\u063a\u0634\u0627\u0621 \u0627\u0644\u0645\u063a\u0637\u064a \u0623\u0648 \u0627\u0644\u0645\u0628\u0637\u0646 \u0644\u0644\u0645\u062e.<\/b><\/td>\nX<\/td>\nx<\/td>\n<\/td>\n<\/td>\nx<\/td>\n\u0627\u0644\u0627\u0646\u0627\u062b<\/b><\/td>\n<\/td>\n<\/tr>\n
x<\/td>\nx<\/td>\n<\/td>\n<\/td>\nx<\/td>\n\u0627\u0644\u0630\u0643\u0648\u0631<\/b><\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0645\u0646 \u0641\u0626\u0629 (\u0628) :<\/strong><\/span><\/p>\n

– \u064a\u0645\u062b\u0644 5% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a<\/p>\n

– \u062a\u0643\u0648\u0646 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0641\u064a\u0647 \u0641\u0642\u0637 \u0641\u064a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 (\u0641\u064a 98% to 100% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646)<\/p>\n

– \u0648\u062a\u0648\u0631\u0645\u0627\u062a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0633\u0645\u0628\u062b\u0627\u0648\u064a ( \u0641\u064a 50% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 )<\/p>\n

– \u0627\u062d\u064a\u0627\u0646\u0627\u064b \u064a\u0643\u0648\u0646 \u0627\u0634\u062f \u0642\u0648\u0629 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 (\u0623) \u062d\u064a\u062b \u0642\u062f \u064a\u0633\u062a\u0644\u0632\u0645 \u0627\u0644\u0627\u0645\u0631 \u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0628\u0639\u062f \u0627\u0644\u0648\u0644\u0627\u062f\u0629<\/p>\n

– \u0642\u062f \u064a\u062d\u062f\u062b \u0644\u0644\u0645\u0648\u0627\u0644\u064a\u062f \u0632\u0648\u0627\u0626\u062f \u0639\u0635\u0628\u064a\u0629 \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648 \u0627\u0644\u0627\u063a\u0634\u064a\u0629 \u0627\u0644\u0645\u0628\u0637\u0646\u0629 \u0644\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0647\u0636\u0645\u064a (\u0641\u064a 98% to 100% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646) \u0645\u062b\u0644 \u0627\u0644\u0644\u0633\u0627\u0646 \u0648 \u0627\u0644\u0634\u0641\u062a\u064a\u0646<\/p>\n

– \u062a\u0636\u062e\u0645 \u0648\u062a\u0648\u0633\u0639 \u0641\u064a \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0645\u0634\u0627\u0643\u0644 \u0641\u064a \u0627\u0644\u0647\u0636\u0645<\/p>\n

– \u0628\u0646\u064a\u0647 \u0637\u0648\u064a\u0644\u0629 \u062a\u0634\u0627\u0628\u0647 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0645\u0627\u0631\u0641\u0627\u0646.<\/p>\n

– \u062a\u062d\u062f\u062b \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0628\u0628 \u0637\u0641\u0631\u0627\u062a \u0645\u0645\u064a\u0632\u0629 \u0641\u064a \u0627\u0644\u062c\u064a\u0646 (\u0631\u064a\u062a\u0632) \u0648 \u0641\u064a \u0627\u0644\u063a\u0627\u0644\u0628 \u0627\u0646\u0647\u0627 \u0637\u0641\u0631\u0629 \u062c\u062f\u064a\u062f\u0629 \u0648 \u0644\u0627 \u064a\u0648\u062c\u062f \u0627\u062d\u062f \u0645\u0635\u0627\u0628 \u0641\u064a \u0627\u0644\u0627\u0633\u0631\u0629 \u0633\u0627\u0628\u0642\u0627\u064b.<\/p>\n\n\n\n\n\n\n
\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629: \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062a\u0648\u0631\u0645\u0627\u062a \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u0628<\/p>\n

\u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a: RET
\n\u064a\u0633\u0628\u0628 \u062a\u0648\u0631\u0645\u0627\u062a \u0641\u064a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 . Werathah<\/td>\n<\/tr>\n

\u0623\u0648\u0631\u0627\u0645 \u0627\u062e\u0631\u0649<\/b><\/td>\n\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633<\/b><\/td>\n\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629<\/b><\/td>\n\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0646\u062e\u0627\u0645\u064a\u0629<\/b><\/td>\n\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u063a\u062f\u0629 \u062c\u0627\u0631 \u062f\u0631\u0642\u064a\u0629<\/b><\/td>\n\u0623\u0648\u0627\u0645<\/b><\/p>\n

\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 <\/b><\/b><\/td>\n

\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 <\/b><\/b><\/td>\n<\/td>\n<\/tr>\n
\u0642\u062f \u064a\u062d\u062f\u062b \u0644\u0644\u0645\u0648\u0627\u0644\u064a\u062f \u0632\u0648\u0627\u0626\u062f \u0639\u0635\u0628\u064a\u0629 \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648 \u0627\u0644\u0627\u063a\u0634\u064a\u0629 \u0627\u0644\u0645\u0628\u0637\u0646\u0629 \u0644\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0647\u0636\u0645\u064a (\u0641\u064a 98% to 100% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646) \u0645\u062b\u0644 \u0627\u0644\u0644\u0633\u0627\u0646 \u0648 \u0627\u0644\u0634\u0641\u062a\u064a\u0646 .\u062a\u0636\u062e\u0645 \u0648\u062a\u0648\u0633\u0639 \u0641\u064a \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u0645\u0634\u0627\u0643\u0644 \u0641\u064a \u0627\u0644\u0647\u0636\u0645 .\u0628\u0646\u064a\u0647 \u0637\u0648\u064a\u0644\u0629 \u062a\u0634\u0627\u0628\u0647 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0645\u0627\u0631\u0641\u0627\u0646.<\/p>\n

 <\/td>\n

<\/td>\n<\/td>\n<\/td>\n<\/td>\nx<\/td>\n\u0627\u0644\u0627\u0646\u0627\u062b<\/b><\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\nx<\/td>\n\u0627\u0644\u0630\u0643\u0648\u0631<\/b><\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0644\u062b<\/span><\/h3>\n

\u0648 \u0627\u0644\u0630\u064a \u064a\u0633\u0645\u0649 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a (Familial Medullary Thyroid Cancer<\/u>) .<\/p>\n

– \u0642\u062f \u064a\u0635\u064a\u0628 \u0628\u0639\u0636 \u0627\u0644\u0627\u0633\u0631 (5% to 35% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a )<\/p>\n

– \u064a\u0635\u064a\u0628 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0641\u0642\u0637 \u0648 \u0628\u062f\u0648\u0646 \u0638\u0647\u0648\u0631 \u0627\u0639\u0631\u0627\u0636 \u0623\u062e\u0631\u0649 \u0641\u064a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062c\u0627\u0631 \u062f\u0631\u0642\u064a\u0629 \u0648 \u0644\u0627 \u0641\u064a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0633\u0645\u0628\u062b\u0627\u0648\u064a \u062d\u062a\u0649 \u0644\u0648 \u062a\u062c\u0627\u0648\u0632 \u0633\u0646 \u0627\u0644\u0645\u0631\u064a\u0636 50 \u0633\u0646\u0647<\/p>\n

– \u0641\u064a \u0627\u0644\u063a\u0627\u0644\u0628 \u0644\u062f\u064a\u0647\u0645 \u0637\u0641\u0631\u0627\u062a \u0645\u0645\u064a\u0632\u0629 \u0641\u064a \u0627\u0644\u062c\u064a\u0646 .<\/p>\n

\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629: \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062a\u0648\u0631\u0645\u0627\u062a \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0623\u0648\u0644 \u0648 \u0627\u0644\u062b\u0627\u0646\u064a
\n\u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a: RET\u0648 MEN1
\n\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u0648\u0631\u0627\u0645: \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0623\u0648\u0644 \u064a\u0633\u0628\u0628 : \u062a\u0648\u0631\u0645\u0627\u062a (\u0641\u064a \u0627\u0644\u0639\u0627\u062f\u0629 \u062d\u0645\u064a\u062f\u0629) \u0641\u064a \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0648 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062c\u0627\u0631 \u062f\u0631\u0642\u064a\u0629 \u0641\u064a \u0627\u0644\u0631\u0642\u0628\u0629 \u0648 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0646\u062e\u0627\u0645\u064a\u0629 \u0641\u064a \u0627\u0644\u0645\u062e. \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u064a\u0633\u0628\u0628 \u062a\u0648\u0631\u0645\u0627\u062a \u0641\u064a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0648\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629 \u0648 \u0641\u064a \u0627\u0644\u0639\u0627\u062f\u0629 \u062a\u0643\u0648\u0646 \u062d\u0645\u064a\u062f\u0629.<\/h3>\n

\u0646\u0633\u0628 \u0627\u0644\u0625\u0635\u0627\u0628\u0629:<\/h3>\n

\u0646\u0633\u0628\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0641\u064a \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0623\u0648\u0644 \u062a\u0635\u0644 \u0627\u0644\u0649 100% \u062e\u0644\u0627\u0644 50 \u0633\u0646\u0647 \u0645\u0646 \u0627\u0644\u0639\u0645\u0631 \u0648 \u0641\u064a \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a \u062a\u0643\u0648\u0646 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0641\u064a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0641\u064a 98% to 100% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0648\u062a\u0648\u0631\u0645\u0627\u062a \u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0633\u0645\u0628\u062b\u0627\u0648\u064a \u0641\u064a 50%.<\/p>\n

\u0627\u0644\u0646\u0635\u0627\u0626\u062d \u0627\u0644\u0627\u0631\u0634\u0627\u062f\u064a\u0629:<\/h3>\n

\u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u0637\u0641\u0631\u0629 \u0641\u064a \u0623\u062d\u062f \u0647\u0630\u0647 \u0627\u0644\u062c\u064a\u0646\u064a\u0646 \u064a\u0646\u0635\u062d \u0628\u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0641\u062d\u0648\u0635\u0627\u062a \u0627\u0644\u062a\u064a \u0630\u0643\u0631\u0646\u0627\u0647\u0627 \u0628\u0634\u0643\u0644 \u062f\u0648\u0631\u064a \u0648 \u064a\u062a\u0627\u0628\u0639 \u0645\u0639 \u0627\u0644\u0637\u0628\u064a\u0628 \u0627\u0644\u0645\u0639\u0627\u0644\u062c \u0628\u0627\u0646\u062a\u0638\u0627\u0645 .<\/p>\n

\u0627\u0644\u0648\u0642\u0627\u064a\u0629:.<\/h3>\n

\u0645\u0646 \u064a\u0631\u062b \u0646\u0633\u062e\u0629 \u0645\u0639\u0637\u0648\u0628\u0629 (\u0637\u0641\u0631\u0629) \u0641\u064a \u0627\u062d\u062f \u0647\u0627\u0630\u064a\u0646 \u0627\u0644\u062c\u064a\u0646\u064a\u0646 \u0644\u062f\u064a\u0647 \u0627\u062d\u062a\u0645\u0627\u0644 \u064a\u0635\u0644 \u0627\u0644\u0649 50% \u0644\u062a\u0648\u0631\u064a\u062b\u0647 \u0627\u0644\u0649 \u0627\u062d\u062f \u0627\u0641\u0631\u0627\u062f \u0630\u0631\u064a\u062a\u0647 \u0641\u064a \u0643\u0644 \u062d\u0645\u0644 \u0648 50% \u0627\u062d\u062a\u0645\u0627\u0644 \u0623\u0646 \u064a\u0631\u062b\u0648\u0627 \u0646\u0633\u062e\u0629 \u0633\u0644\u064a\u0645\u0629 \u0645\u0646\u0647 \u0644\u0630\u0644\u0643 \u064a\u0646\u0635\u062d \u0628\u0641\u062d\u0635 \u0627\u0644\u0639\u0627\u0626\u0644\u0629 \u0644\u0644\u0648\u0642\u0627\u064a\u0629.<\/p>\n

<\/h1>\n

\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a \u0641\u0631\u0648\u0645\u064a\u0646\u064a<\/span>
\n Li-Fraumeni Syndrome<\/span><\/h1>\n

\u0645\u0646 \u0623\u0634\u0647\u0631 \u0645\u062a\u0644\u0627\u0632\u0645\u0627\u062a \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0648\u0644\u0643\u0646\u0647\u0627 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0646\u0627\u062f\u0631\u0629. \u062a\u0633\u0628\u0628 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0628\u0645\u0627 \u0641\u064a\u0647\u0627:<\/p>\n

– \u0627\u0648\u0631\u0627\u0645 \u0627\u0644\u0627\u0646\u0633\u062c\u0629(\u0633\u0627\u0631\u0643\u0648\u0645\u0627 )\u0648 \u0627\u0644\u062a\u064a \u0642\u062f \u062a\u0635\u064a\u0628 \u0627\u0644\u0639\u0638\u0645 \u0648 \u0627\u0644\u0627\u0646\u0633\u062c\u0629 \u0627\u0644\u0636\u0627\u0645\u0629 .<\/p>\n

– \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a<\/p>\n

– \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629<\/p>\n

– \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062f\u0645 ( \u0627\u0644\u064a\u0648\u0643\u064a\u0645\u064a\u0627)<\/p>\n

– \u0627\u0644\u0645\u062e<\/p>\n

– \u0627\u0644\u0631\u0626\u0629<\/p>\n

– \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u064a\u0645\u0641\u0627\u0648\u064a\u0629 (\u0644\u064a\u0645\u0641\u0648\u0645\u0627)<\/p>\n

\u0648 \u0645\u0639\u0638\u0645 \u0647\u0630\u0647 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0642\u062f \u062a\u0638\u0647\u0631 \u0641\u064a \u0633\u0646 \u0627\u0644\u0637\u0641\u0648\u0644\u0629 \u0623\u0645\u0627 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0641\u0642\u062f \u064a\u0638\u0647\u0631 \u0628\u0639\u062f \u0633\u0646 \u0627\u0644\u0628\u0644\u0648\u063a. . \u0647\u0630\u0647 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0633\u0628\u0628\u0647\u0627 \u0637\u0641\u0631\u0629 \u0641\u064a \u062c\u064a\u0646 \u0627\u0633\u0645\u0647 \u0628\u064a 54 (TP53) \u062d\u064a\u062b \u064a\u0639\u0645\u0644 \u0647\u0630\u0627 \u0627\u0644\u062c\u064a\u0646 \u0639\u0644\u0649 \u062a\u062b\u0628\u064a\u0637 \u062d\u062f\u0648\u062b \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0625\u064a\u0642\u0627\u0641 \u0627\u0646\u0642\u0633\u0627\u0645 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u063a\u064a\u0631 \u0637\u0628\u064a\u0639\u064a\u0629. \u0648 \u0641\u064a \u0628\u0639\u0636 \u062d\u0627\u0644\u0627\u062a \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a \u0641\u0631\u0648\u0645\u064a\u0646\u064a \u064a\u0643\u0648\u0646 \u0627\u0644\u0633\u0628\u0628 \u0641\u064a \u0637\u0641\u0631\u0629 \u0641\u064a \u062c\u064a\u0646 \u0627\u062e\u0631 \u0627\u0633\u0645\u0647 \u062a\u0634\u064a\u06432 (CHEK2 ).
\n\u0627\u0644\u0634\u062e\u0635 \u0627\u0644\u0630\u064a \u064a\u0631\u062b \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0639\u0637\u0648\u0628 \u0644\u062f\u064a\u0647 \u0646\u0633\u0628\u0629 \u0627\u0639\u0644\u0649 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0623\u0648\u0631\u0627\u0645 \u0628\u0646\u0633\u0628\u0629 50% \u062e\u0644\u0627\u0644 40 \u0633\u0646\u0629 \u0645\u0646 \u0639\u0645\u0631\u0647 \u0648\u0646\u0633\u0628\u0647 \u0645\u0646\u0647\u0645 \u064a\u0635\u0627\u0628 \u0642\u0628\u0644 \u0633\u0646 2 \u0633\u0646\u0647. \u0648 \u0646\u0633\u0628\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u062a\u0635\u0644 \u0627\u0644\u0649 90% \u0639\u0646\u062f \u0628\u0644\u0648\u063a\u0647\u0645 60 \u0639\u0627\u0645 .\u0648 \u0642\u062f \u062a\u0643\u0648\u0646 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0627\u0643\u062b\u0631 \u0641\u064a \u0627\u0644\u0646\u0633\u0627\u0621 \u0644\u0623\u0646\u0647\u0646 \u0627\u0643\u062b\u0631 \u0639\u0631\u0636\u0647 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a( \u0641\u0645\u0639\u062f\u0644 \u0627\u0635\u0627\u0628\u062a\u0647\u0646 \u0641\u064a \u0633\u0646 37 \u0633\u0646\u0647 \u0648\u0642\u062f \u064a\u0643\u0648\u0646 \u0641\u064a \u0643\u0644\u0627 \u0627\u0644\u062b\u062f\u064a\u064a\u0646) . \u0648\u0644\u0627 \u064a\u0628\u062f\u0648\u0627 \u0627\u0646 \u0647\u0646\u0627\u0643 \u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0644\u062f\u0649 \u0627\u0644\u0631\u062c\u0627\u0644 \u0648 \u0644\u0627 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u062a\u0627. \u0648 \u0641\u064a \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u064a\u0634\u064a\u0639 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0639\u0638\u0627\u0645 ( \u0627\u0648\u0633\u062a\u064a\u0648 \u0633\u0627\u0631\u0643\u0648\u0645\u0627 ) \u0648 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0627\u0646\u0633\u062c\u0629 ( \u0633\u0627\u0631\u0643\u0648\u0645\u0627 ) \u0643\u0630\u0644\u0643 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062f\u0645 \u0648 \u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0645\u062e \u0648 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629 \u0648 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0623\u062e\u0631\u0649 \u0627\u0644\u0646\u0627\u062f\u0631\u0629. \u0648\u0645\u0646 \u064a\u0634\u0641\u0649 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0641\u064a \u0627\u0644\u0637\u0641\u0648\u0644\u0629 \u0642\u062f \u064a\u0635\u0627\u0628 \u0628\u0623\u0648\u0631\u0627\u0645 \u0645\u0639 \u0627\u0644\u0639\u0645\u0631 \u062e\u0627\u0635\u0629 \u0641\u064a \u0627\u0644\u0623\u0645\u0627\u0643\u0646 \u0627\u0644\u062a\u064a \u062a\u0639\u0631\u0636\u0647 \u0644\u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0633\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u0643\u062b\u0641\u0629 \u0644\u0627\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0647\u0630\u0647 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u062f\u064a\u0647\u0645 \u062d\u0633\u0627\u0633\u064a\u0629 \u0645\u0646 \u0627\u0644\u0627\u0634\u0639\u0629 \u0641\u062a\u0632\u064a\u062f \u0645\u0646 \u0627\u062d\u062a\u0645\u0627\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0623\u0648\u0631\u0627\u0645.<\/p>\n

\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629: \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a \u0641\u0631\u0648\u0645\u064a\u0646\u064a
\n\u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a: TP53\u060c CHEK2 \u0648 \u062c\u064a\u0646 \u062b\u0627\u0644\u062b \u0645\u062c\u0647\u0648\u0644
\n\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u0648\u0631\u0627\u0645: \u0627\u0648\u0631\u0627\u0645 \u0627\u0644\u0627\u0646\u0633\u062c\u0629 \u0627\u0644\u0645\u0639\u0631\u0648\u0641\u0629 \u0628\u0627\u0644\u0633\u0627\u0631\u0643\u0648\u0645\u0627 \u0648 \u0627\u0644\u062a\u064a \u0642\u062f \u062a\u0635\u064a\u0628 \u0627\u0644\u0639\u0638\u0645 ( \u0623\u0648\u0633\u062a\u064a\u0648 \u0633\u0627\u0631\u0643\u0648\u0645\u0627)\u0648 \u0627\u0644\u0627\u0646\u0633\u062c\u0629 \u0627\u0644\u0636\u0627\u0645\u0629 \u060c\u0643\u0630\u0644\u0643 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629 \u0648 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062f\u0645 (\u0627\u0644\u064a\u0648\u0643\u064a\u0645\u064a\u0627) \u0648\u0627\u0644\u0645\u062e \u0648\u0627\u0644\u063a\u062f\u062f \u0627\u0644\u064a\u0645\u0641\u0627\u0648\u064a\u0629 \u0648 \u063a\u064a\u0631\u0647\u0627 \u0645\u0646 \u0627\u0644\u0627\u0648\u0631\u0627\u0645.<\/h3>\n

\u0646\u0633\u0628 \u0627\u0644\u0625\u0635\u0627\u0628\u0629:<\/h3>\n

\u0646\u0633\u0628\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0641\u064a \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0643\u0644\u0627\u0633\u064a\u0643\u064a \u062a\u0635\u0644 \u0627\u0644\u0649 50% \u0639\u0646\u062f \u0633\u0646 \u0627\u0644\u0623\u0631\u0628\u0639\u064a\u0646 \u064890% \u0639\u0646\u062f \u0633\u0646 \u0627\u0644\u0633\u062a\u064a\u0646.<\/p>\n

\u0627\u0644\u0646\u0635\u0627\u0626\u062d \u0627\u0644\u0627\u0631\u0634\u0627\u062f\u064a\u0629:<\/h3>\n

\u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u0637\u0641\u0631\u0629 \u0641\u064a \u0623\u062d\u062f \u0647\u0630\u0647 \u0627\u0644\u062c\u064a\u0646\u064a\u0646 \u064a\u0646\u0635\u062d \u0628\u0625\u062c\u0631\u0627\u0621 \u0641\u062d\u0648\u0635\u0627\u062a \u062f\u0648\u0631\u064a\u0629 \u0644\u0644\u0643\u0634\u0641 \u0639\u0646 \u0647\u0630\u0647 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0641\u064a \u0648\u0642\u062a \u0645\u0628\u0643\u0631 .<\/p>\n

\u0627\u0644\u0648\u0642\u0627\u064a\u0629:<\/h3>\n

\u0645\u0646 \u064a\u0631\u062b \u0646\u0633\u062e\u0629 \u0645\u0639\u0637\u0648\u0628\u0629 (\u0637\u0641\u0631\u0629) \u0641\u064a \u0627\u062d\u062f \u0647\u0627\u0630\u064a\u0646 \u0627\u0644\u062c\u064a\u0646\u064a\u0646 \u0644\u062f\u064a\u0647 \u0627\u062d\u062a\u0645\u0627\u0644 \u064a\u0635\u0644 \u0627\u0644\u0649 50% \u0644\u062a\u0648\u0631\u064a\u062b\u0647 \u0627\u0644\u0649 \u0627\u062d\u062f \u0627\u0641\u0631\u0627\u062f \u0630\u0631\u064a\u062a\u0647 \u0641\u064a \u0643\u0644 \u062d\u0645\u0644 \u0648 50% \u0627\u062d\u062a\u0645\u0627\u0644 \u0623\u0646 \u064a\u0631\u062b\u0648\u0627 \u0646\u0633\u062e\u0629 \u0633\u0644\u064a\u0645\u0629 \u0645\u0646\u0647 \u0644\u0630\u0644\u0643 \u064a\u0646\u0635\u062d \u0628\u0641\u062d\u0635 \u0627\u0644\u0639\u0627\u0626\u0644\u0629 \u0644\u0644\u0648\u0642\u0627\u064a\u0629.<\/h3>\n

\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0625\u0636\u0627\u0641\u064a\u0629:<\/h3>\n

\u0631\u0627\u062c\u0639 \u0627\u0644\u062f\u0643\u062a\u0648\u0631 \u0644\u064a \u0648 \u0641\u0631\u0648\u0645\u064a\u0646\u064a \u0641\u064a \u0639\u0627\u0645 1969 \u0627\u0644\u0633\u062c\u0644 \u0627\u0644\u0637\u0628\u064a 648 \u0637\u0641\u0644 \u0645\u0635\u0627\u0628 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0639\u0636\u0644\u0627\u062a (\u0631\u0627\u0628\u062f\u0648\u0645\u064a\u0648\u0633\u0631\u0643\u0648\u0645\u0627) \u0648 \u0648\u062c\u062f \u0627\u0631\u0628\u0639 \u0627\u0633\u0631 \u0644\u062f\u064a\u0647\u0627 \u0627\u062e\u0648\u0627\u0646 \u0627\u0648 \u0623\u0628\u0646\u0627\u0621 \u0639\u0645 \u0644\u062f\u064a\u0647\u0645 \u0623\u064a\u0636\u0627 \u0633\u0631\u0637\u0627\u0646 \u0641\u064a \u0627\u0644\u0627\u0646\u0633\u062c\u0629 ( \u0633\u0627\u0631\u0643\u0648\u0645\u0627) \u0648 \u0643\u0630\u0644\u0643 \u0647\u0646\u0627\u0643 \u0645\u0635\u0628\u064a\u0646 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648 \u0623\u0648\u0631\u0627\u0645 \u0627\u062e\u0631\u0649 .\u0645\u0646\u0630 \u0630\u0644\u0643 \u0627\u0644\u0648\u0642\u062a \u0639\u0631\u0641 \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a \u0641\u0631\u0648\u0645\u064a\u0646\u064a.<\/p>\n\n\n\n\n\n\n
\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629: – \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a \u0641\u0631\u0648\u0645\u064a\u0646\u064a<\/p>\n

\u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a: TP53\u060c CHEK2 \u0648 \u062c\u064a\u0646 \u062b\u0627\u0644\u062b \u0645\u062c\u0647\u0648\u0644
\n\u0627\u0648\u0631\u0627\u0645 \u0627\u0644\u0627\u0646\u0633\u062c\u0629(\u0633\u0627\u0631\u0643\u0648\u0645\u0627 )\u0648 \u0627\u0644\u062a\u064a \u0642\u062f \u062a\u0635\u064a\u0628 \u0627\u0644\u0639\u0638\u0645 \u0648 \u0627\u0644\u0627\u0646\u0633\u062c\u0629 \u0627\u0644\u0636\u0627\u0645\u0629 \u060c\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u060c \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629 \u060c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062f\u0645 ( \u0627\u0644\u064a\u0648\u0643\u064a\u0645\u064a\u0627)\u060c\u0627\u0644\u0645\u062e \u060c\u0627\u0644\u0631\u0626\u0629 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u064a\u0645\u0641\u0627\u0648\u064a\u0629 (\u0644\u064a\u0645\u0641\u0648\u0645\u0627). Werathah<\/td>\n<\/tr>\n

\u0623\u0648\u0631\u0627\u0645 \u0627\u062e\u0631\u0649<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u062e<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u0626\u0629<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062f\u0645<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0628\u064a\u0636<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0633\u0627\u0631\u0643\u0648\u0645\u0627<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a<\/b><\/b><\/td>\n\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 <\/b><\/b><\/td>\n<\/tr>\n
<\/td>\nX<\/td>\nX<\/td>\nX<\/td>\n<\/td>\nx<\/td>\n<\/td>\nx<\/td>\nx<\/td>\n\u0627\u0644\u0627\u0646\u0627\u062b<\/b><\/td>\n<\/tr>\n
x<\/td>\nx<\/td>\nx<\/td>\n<\/td>\nx<\/td>\n<\/td>\n<\/td>\n<\/td>\n\u0627\u0644\u0630\u0643\u0648\u0631<\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0643\u0627\u0648\u062f\u0646<\/span>
\n Cowden syndrome<\/span><\/h1>\n

\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0643\u0627\u0648\u062f\u0646 \u062a\u0639\u0631\u0641 \u0623\u064a\u0636\u0627 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0647\u0645\u0631\u062a\u0648\u0645\u0627 \u0627\u0644\u0645\u062a\u0639\u062f\u062f\u0629. \u0648 \u0627\u0644\u0647\u0645\u0631\u062a\u0648\u0645\u0627 \u0647\u064a \u062a\u0634\u062e\u064a\u0635 \u0646\u0633\u064a\u062c\u064a \u0644\u0627\u0646\u0648\u0627\u0639 \u0645\u0646 \u0627\u0644\u0623\u0648\u0631\u0627\u0645. \u0648\u0647\u0630\u0647 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0646\u0627\u062f\u0631\u0629 \u0641\u0647\u064a \u062a\u0635\u064a\u0628 \u0648\u0627\u062f \u0645\u0646 \u0643\u0644 200 \u0627\u0644\u0641 \u0646\u0633\u0645\u0629 .\u0648 \u0646\u0638\u0631\u0627 \u0644\u0627\u0646 \u0627\u0639\u0631\u0627\u0636\u0647\u0627 \u0642\u062f \u0644\u0627 \u062a\u0643\u0648\u0646 \u0648\u0627\u0636\u062d\u0629 \u0641\u0642\u062f \u0644\u0627 \u064a\u062a\u0645 \u062a\u0634\u062e\u064a\u0635\u0647\u0627 \u0628\u0633\u0647\u0648\u0644\u0647 . \u0645\u0646 \u0627\u0644\u0627\u0639\u0631\u0627\u0636 \u0627\u0644\u0645\u0634\u0647\u0648\u0631\u0629 \u0639\u0646 \u0647\u0630\u0647 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0647\u0648 \u0643\u0628\u0631 \u062d\u062c\u0645 \u0627\u0644\u0631\u0623\u0633 \u0648 \u0638\u0647\u0648\u0631 \u0628\u0639\u0636 \u0627\u0644\u0628\u0642\u0639 \u0627\u0644\u0645\u0644\u0648\u0646\u0629 \u0639\u0644\u0649 \u0627\u0644\u0644\u0633\u0627\u0646 \u0648 \u0627\u0644\u0623\u0639\u0636\u0627\u0621 \u0627\u0644\u062a\u0646\u0627\u0633\u0644\u064a\u0629 \u0648 \u0638\u0647\u0648\u0631 \u062a\u0648\u0631\u0645\u0627\u062a \u062d\u0645\u064a\u062f\u0629 (\u0632\u0648\u0627\u0626\u062f \u0644\u062d\u0645\u064a\u0629 ) \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648\u0627\u0644\u062c\u0644\u062f \u0648\u0627\u0644\u0645\u062e \u0648 \u0627\u0644\u062b\u062f\u064a \u0648 \u0627\u0644\u0631\u062d\u0645 \u0648 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0648 \u0641\u064a \u0623\u0645\u0627\u0643\u0646 \u0623\u062e\u0631\u0649 \u0645\u0646 \u0627\u0644\u062c\u0633\u0645 . \u0648 \u0642\u062f \u062a\u062d\u062f\u062b \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0628\u0646\u0633\u0628\u0629 25 \u0627\u0644\u0649 50% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0647\u0630\u0647 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062e\u0644\u0627\u0644 \u0645\u0631\u062d\u0644\u0629 \u062d\u064a\u0627\u062a\u0647\u0645 \u0648 \u0645\u0639\u0638\u0645\u0647\u0627 \u062d\u0645\u064a\u062f\u0629 \u0648 \u0644\u0643\u0646 \u0628\u0639\u0636\u0647\u0627 \u0642\u062f \u0644\u0627 \u064a\u0643\u0648\u0646 \u062d\u0645\u064a\u062f.<\/p>\n

\u062a\u062d\u062f\u062b \u0647\u0630\u0647 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0628\u0633\u0628\u0628 \u0637\u0641\u0631\u0629 \u0641\u064a \u062c\u064a\u0646 \u0627\u0633\u0645\u0647 \u0628\u064a \u062a\u0646 (PTEN) \u062d\u064a\u062b \u064a\u0639\u0645\u0644 \u0647\u0630\u0627 \u0627\u0644\u062c\u064a\u0646 \u0639\u0644\u0649 \u062a\u062b\u0628\u064a\u0637 \u062d\u062f\u0648\u062b \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0648 \u064a\u062a\u0645 \u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u0637\u0641\u0631\u0629 \u0641\u064a 10 \u0627\u0644\u0649 35% \u0645\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0647\u0630\u0647 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0648 \u0647\u0648 \u064a\u0646\u062a\u0642\u0644 \u0628\u0627\u0644\u0648\u0631\u0627\u062b\u0629 \u0627\u0644\u0633\u0627\u0626\u062f\u0629 . \u0639\u0644\u0645\u0627\u064b \u0623\u0646 \u0645\u0639\u0638\u0645 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u062a\u0643\u0648\u0646 \u0628\u0633\u0628\u0628 \u0637\u0641\u0631\u0629 \u062c\u062f\u064a\u062f\u0629 \u0644\u064a\u0633\u062a \u0645\u0648\u062c\u0648\u062f\u0629 \u0639\u0646 \u0627\u0644\u0648\u0627\u0644\u062f\u064a\u0646.<\/p>\n

\u0627\u0644\u0634\u062e\u0635 \u0627\u0644\u0630\u064a \u064a\u0631\u062b \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0639\u0637\u0648\u0628 \u0644\u062f\u064a\u0647 \u0646\u0633\u0628\u0629 \u0627\u0639\u0644\u0649 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0623\u0648\u0631\u0627\u0645 \u0628\u0646\u0633\u0628\u0629 50% \u062e\u0644\u0627\u0644 40 \u0633\u0646\u0629 \u0645\u0646 \u0639\u0645\u0631\u0647 \u0648\u0646\u0633\u0628\u0647 \u0645\u0646\u0647\u0645 \u064a\u0635\u0627\u0628 \u0642\u0628\u0644 \u0633\u0646 \u0627\u0644\u0633\u0646\u062a\u064a\u0646. \u0648 \u0646\u0633\u0628\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u062a\u0635\u0644 \u0627\u0644\u0649 90% \u0639\u0646\u062f \u0628\u0644\u0648\u063a\u0647\u0645 60 \u0639\u0627\u0645 .\u0648 \u0642\u062f \u062a\u0643\u0648\u0646 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0627\u0643\u062b\u0631 \u0641\u064a \u0627\u0644\u0646\u0633\u0627\u0621 \u0644\u0623\u0646\u0647\u0646 \u0627\u0643\u062b\u0631 \u0639\u0631\u0636\u0647 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a( \u0641\u0645\u0639\u062f\u0644 \u0627\u0635\u0627\u0628\u062a\u0647\u0646 \u0641\u064a \u0633\u0646 37 \u0633\u0646\u0647 \u0648\u0642\u062f \u064a\u0643\u0648\u0646 \u0641\u064a \u0643\u0644\u0627 \u0627\u0644\u062b\u062f\u064a\u064a\u0646) . \u0648\u0644\u0627 \u064a\u0628\u062f\u0648\u0627 \u0627\u0646 \u0647\u0646\u0627\u0643 \u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0644\u062f\u0649 \u0627\u0644\u0631\u062c\u0627\u0644 \u0648 \u0644\u0627 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0631\u0648\u0633\u062a\u0627\u062a\u0627. \u0648 \u0641\u064a \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u064a\u0634\u064a\u0639 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0639\u0638\u0627\u0645 ( \u0627\u0648\u0633\u062a\u064a\u0648 \u0633\u0627\u0631\u0643\u0648\u0645\u0627 ) \u0648 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0627\u0646\u0633\u062c\u0629 ( \u0633\u0627\u0631\u0643\u0648\u0645\u0627 ) \u0643\u0630\u0644\u0643 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062f\u0645 \u0648 \u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0645\u062e \u0648 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629 \u0648 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0623\u062e\u0631\u0649 \u0627\u0644\u0646\u0627\u062f\u0631\u0629. \u0648\u0645\u0646 \u064a\u0634\u0641\u0649 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0641\u064a \u0627\u0644\u0637\u0641\u0648\u0644\u0629 \u0642\u062f \u064a\u0635\u0627\u0628 \u0628\u0623\u0648\u0631\u0627\u0645 \u0645\u0639 \u0627\u0644\u0639\u0645\u0631 \u062e\u0627\u0635\u0629 \u0641\u064a \u0627\u0644\u0623\u0645\u0627\u0643\u0646 \u0627\u0644\u062a\u064a \u062a\u0639\u0631\u0636\u0647 \u0644\u0644\u0623\u0634\u0639\u0629 \u0627\u0644\u0633\u064a\u0646\u064a\u0629 \u0627\u0644\u0645\u0643\u062b\u0641\u0629 \u0644\u0627\u0646 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0647\u0630\u0647 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u062f\u064a\u0647\u0645 \u062d\u0633\u0627\u0633\u064a\u0629 \u0645\u0646 \u0627\u0644\u0627\u0634\u0639\u0629 \u0641\u062a\u0632\u064a\u062f \u0645\u0646 \u0627\u062d\u062a\u0645\u0627\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0623\u0648\u0631\u0627\u0645.<\/p>\n

 <\/p>\n

\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629: \u0643\u0627\u0648\u062f\u0646
\n\u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a: PTEN
\n\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u0648\u0631\u0627\u0645: \u062a\u0648\u0631\u0645\u0627\u062a \u062d\u0645\u064a\u062f\u0629 \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648\u0627\u0644\u062c\u0644\u062f \u0648\u0627\u0644\u0645\u062e \u0648\u0627\u0644\u062b\u062f\u064a \u0648\u0627\u0644\u0631\u062d\u0645 \u0648\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0648\u0641\u064a \u0623\u0645\u0627\u0643\u0646 \u0623\u062e\u0631\u0649 \u0645\u0646 \u0627\u0644\u062c\u0633\u0645 \u0648\u0628\u0639\u0636\u0647\u0627 \u064a\u0643\u0648\u0646 \u063a\u064a\u0631 \u062d\u0645\u064a\u062f.<\/h4>\n

\u0646\u0633\u0628 \u0627\u0644\u0625\u0635\u0627\u0628\u0629:<\/h4>\n

\u0646\u0633\u0628\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u062e\u0644\u0627\u0644 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0639\u0645\u0631 \u062a\u0643\u0648\u0646 \u0641\u064a \u0627\u0639\u0644\u0627\u0647\u0627 \u0641\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648\u0642\u062f \u064a\u0635\u0644 85% \u0648 \u0642\u062f \u064a\u0635\u0644 \u0627\u0644\u0649 50% \u0639\u0646\u062f \u0633\u0646 \u0627\u0644\u062e\u0645\u0633\u064a\u0646 \u0639\u0627\u0645. \u0648 \u0627\u062d\u062a\u0645\u0627\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0648 \u0627\u0644\u0631\u062d\u0645 \u062a\u0642\u0631\u064a\u0628 30 \u0627\u0644\u0649 35% .<\/p>\n

\u0627\u0644\u0646\u0635\u0627\u0626\u062d \u0627\u0644\u0627\u0631\u0634\u0627\u062f\u064a\u0629:<\/h4>\n

\u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u0637\u0641\u0631\u0629 \u0641\u064a \u0623\u062d\u062f \u0647\u0630\u0647 \u0627\u0644\u062c\u064a\u0646\u064a\u0646 \u064a\u0646\u0635\u062d \u0628\u0625\u062c\u0631\u0627\u0621 \u0641\u062d\u0648\u0635\u0627\u062a \u062f\u0648\u0631\u064a\u0629 \u0644\u0644\u0643\u0634\u0641 \u0639\u0646 \u0647\u0630\u0647 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0641\u064a \u0648\u0642\u062a \u0645\u0628\u0643\u0631 .<\/p>\n

\u0627\u0644\u0648\u0642\u0627\u064a\u0629:<\/h4>\n

\u0645\u0646 \u064a\u0631\u062b \u0646\u0633\u062e\u0629 \u0645\u0639\u0637\u0648\u0628\u0629 (\u0637\u0641\u0631\u0629) \u0641\u064a \u0627\u062d\u062f \u0647\u0627\u0630\u064a\u0646 \u0627\u0644\u062c\u064a\u0646\u064a\u0646 \u0644\u062f\u064a\u0647 \u0627\u062d\u062a\u0645\u0627\u0644 \u064a\u0635\u0644 \u0627\u0644\u0649 50% \u0644\u062a\u0648\u0631\u064a\u062b\u0647 \u0627\u0644\u0649 \u0627\u062d\u062f \u0627\u0641\u0631\u0627\u062f \u0630\u0631\u064a\u062a\u0647 \u0641\u064a \u0643\u0644 \u062d\u0645\u0644 \u0648 50% \u0627\u062d\u062a\u0645\u0627\u0644 \u0623\u0646 \u064a\u0631\u062b\u0648\u0627 \u0646\u0633\u062e\u0629 \u0633\u0644\u064a\u0645\u0629 \u0645\u0646\u0647 \u0644\u0630\u0644\u0643 \u064a\u0646\u0635\u062d \u0628\u0641\u062d\u0635 \u0627\u0644\u0639\u0627\u0626\u0644\u0629 \u0644\u0644\u0648\u0642\u0627\u064a\u0629.<\/p>\n

\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0625\u0636\u0627\u0641\u064a\u0629: \u0643\u0648\u062f\u0646 ……<\/h4>\n\n\n\n\n\n\n
\n

\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629: \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0643\u0627\u0648\u062f\u0646<\/h3>\n

\u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646\u0627\u062a: PTEN
\n\u062a\u0648\u0631\u0645\u0627\u062a \u062d\u0645\u064a\u062f\u0629 \u0648 \u063a\u064a\u0631 \u062d\u0645\u064a\u062f\u0629 \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648\u0627\u0644\u062c\u0644\u062f \u0648\u0627\u0644\u0645\u062e \u0648\u0627\u0644\u062b\u062f\u064a \u0648\u0627\u0644\u0631\u062d\u0645 \u0648\u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0648\u0641\u064a \u0623\u0645\u0627\u0643\u0646 \u0623\u062e\u0631\u0649 \u0645\u0646 \u0627\u0644\u062c\u0633\u0645 Werathah<\/h3>\n<\/td>\n<\/tr>\n

\u0623\u0648\u0631\u0627\u0645 \u0627\u062e\u0631\u0649<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u062e<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062c\u0644\u062f<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0627\u0645\u0639\u0627\u0621<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0631\u062d\u0645<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a<\/b><\/b><\/td>\n\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 <\/b><\/b><\/td>\n<\/tr>\n
<\/td>\nX<\/td>\nX<\/td>\nX<\/td>\nx<\/td>\nx<\/td>\nx<\/td>\n\u0627\u0644\u0627\u0646\u0627\u062b<\/b><\/td>\n<\/tr>\n
x<\/td>\nx<\/td>\nx<\/td>\nx<\/td>\n<\/td>\n<\/td>\n\u0627\u0644\u0630\u0643\u0648\u0631<\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0632\u0648\u0627\u0626\u062f \u0627\u0644\u0644\u062d\u0645\u064a\u0629 \u0627\u0644\u063a\u062f\u064a\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a (\u0641\u0627\u0628)<\/span>
\n Familial Adenomatous Polyposis (FAP)<\/span><\/h1>\n

\u0645\u0646 \u0623\u0634\u0647\u0631 \u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u0628\u0628 \u0632\u0648\u0627\u0626\u062f \u0644\u062d\u0645\u064a\u0629 \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0648 \u062a\u0624\u062f\u064a \u0627\u0644\u0649 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 . \u0648 \u0627\u0644\u0632\u0648\u0627\u0626\u062f \u0627\u0644\u0644\u062d\u0645\u064a\u0629 \u0641\u064a \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u062a\u0633\u0645\u0649 \u0627\u064a\u0636\u0627\u064b \u0627\u0644\u0633\u0644\u064a\u0644\u0647 ( Polyp) \u0648 \u0647\u064a \u0627\u0644\u0645\u0635\u0637\u0644\u062d \u0627\u0644\u0639\u0644\u0645\u064a \u0644\u062a\u0648\u0631\u0645\u0627\u062a \u062d\u0645\u064a\u062f\u0629 \u062a\u0638\u0647\u0631 \u0641\u064a \u0627\u0644\u0642\u0648\u0644\u0648\u0646. \u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0633\u0628\u0628\u0647 \u0637\u0641\u0631\u0629 \u0641\u064a \u062c\u064a\u0646 \u064a\u0633\u0645\u0649 \u0623\u064a \u0628\u064a \u0633\u064a (APC) \u0648\u0647\u0648 \u064a\u0639\u0645\u0644 \u0641\u064a \u0645\u0647\u0645\u0629 \u062a\u0648\u0635\u064a\u0644 \u0627\u0644\u0625\u0634\u0627\u0631\u0627\u062a \u0628\u062f\u0627\u062e\u0644 \u0645\u0646 \u062c\u062f\u0627\u0631 \u0627\u0644\u062e\u0644\u064a\u0629 \u0627\u0644\u0649 \u062f\u0627\u062e\u0644\u0647\u0627 \u0648 \u0628\u0645\u0647\u0645\u0629 \u0627\u0644\u0627\u0644\u062a\u0635\u0627\u0642 \u0628\u064a\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627.
\n\u0647\u0646\u0627\u0643 \u062b\u0644\u0627\u062b \u0623\u0646\u0648\u0627\u0639 \u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u0645\u0631\u0636 :\u0645\u0646\u0647\u0627 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0634\u0627\u0626\u0639 \u0648 \u0647\u0648 \u0645\u0627 \u064a\u0639\u0631\u0641 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0641\u0627\u0628 () \u062c\u064a\u062b \u0627\u0644\u0634\u062e\u0635 \u0627\u0644\u0630\u064a \u064a\u0631\u062b \u0646\u0633\u062e\u0629 \u0645\u0639\u0637\u0648\u0628\u0629 \u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u062c\u064a\u0646 \u064a\u062a\u0643\u0648\u0646 \u0644\u062f\u064a\u0647 \u0632\u0648\u0627\u0626\u062f \u0644\u062d\u0645\u064a\u0629 \u0628\u0627\u0644\u0645\u0626\u0627\u062a \u0648 \u0627\u0644\u0627\u0644\u0627\u0641 \u0641\u064a \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0642\u0628\u0644 \u0633\u0646 \u0627\u0644\u062b\u0644\u0627\u062b\u064a\u0646 \u0639\u0627\u0645 \u0645\u0646 \u0627\u0644\u0639\u0645\u0631 \u0648 \u0627\u0630\u0627 \u0644\u0645 \u064a\u062a\u0645 \u0627\u0632\u0627\u0644\u062a\u0647\u0627 \u0627\u0648 \u0627\u0633\u062a\u0623\u0635\u0644 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0641\u0627\u0646 \u0627\u0644\u0645\u0635\u0627\u0628 \u064a\u0635\u0627\u0628 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0628\u0646\u0633\u0628\u0629 100%.
\n\u0648 \u0647\u0646\u0627\u0643 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0623\u0642\u0644 \u0634\u062f\u0629 \u0648 \u064a\u0633\u0645\u0649 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0632\u0648\u0627\u0626\u062f \u0627\u0644\u0644\u062d\u0645\u064a\u0629 \u0627\u0644\u063a\u062f\u064a\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a \u0627\u0644\u0645\u0648\u0647\u0646 \u0648 \u064a\u0643\u0648\u0646 \u0641\u064a\u0647 \u0639\u062f\u062f \u0627\u0644\u0632\u0648\u0627\u0626\u062f \u0627\u0644\u0644\u062d\u0645\u064a\u0629 \u0627\u0642\u0644 ( \u0639\u062f\u062f \u0627\u0644\u0632\u0648\u0627\u0626\u062f \u0627\u0644\u0644\u062d\u0645\u064a\u0629 \u0627\u0642\u0644 \u0645\u0646 100 )\u0648 \u062a\u062d\u062f\u062b \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0641\u064a \u0639\u0645\u0631 \u0627\u0643\u0628\u0631.<\/p>\n

\u0648 \u0647\u0646\u0627\u0643 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0644\u062b \u064a\u0639\u0631\u0641 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062c\u0627\u0631\u062f\u0646\u0631 (Gardner syndrome) \u062d\u064a\u062b \u064a\u062d\u062f\u062b \u0632\u0648\u0627\u0626\u062f \u0644\u062d\u0645\u064a\u0629 \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0643\u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0634\u0627\u0626\u0639 \u0625\u0636\u0627\u0641\u0629 \u0627\u0644\u0649 \u0623\u0648\u0631\u0627\u0645 \u062d\u0645\u064a\u062f\u0629 \u0641\u064a \u0623\u062c\u0632\u0627\u0621 \u0623\u062e\u0631\u0649 \u0645\u0646 \u0627\u0644\u062c\u0633\u0645 \u0645\u062b\u0644 \u062a\u0636\u062e\u0645 \u0628\u0635\u064a\u0644\u0627\u062a \u0627\u0644\u0634\u0639\u0631 \u0648 \u0623\u0643\u064a\u0627\u0633 \u0648 \u062a\u0644\u064a\u0641 \u0641\u064a \u0627\u0644\u062c\u0644\u062f \u0648 \u062a\u0648\u0631\u0645\u0627\u062a \u0623\u062e\u0631\u0649 \u0641\u064a \u0627\u0644\u0639\u0638\u0627\u0645 \u0648 \u0627\u0644\u0641\u0643 \u0648 \u0627\u0644\u0627\u0646\u0633\u062c\u0629 (desmoids) \u0648 \u0627\u0644\u0645\u062e \u0648 \u0623\u062c\u0632\u0627\u0621 \u0623\u062e\u0631\u0649 \u0645\u0646 \u0627\u0644\u062c\u0633\u0645.<\/p>\n

\u0643\u0645\u0627 \u064a\u0637\u0644\u0642 \u0623\u0633\u0645 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062a\u0648\u0631\u0643\u0648\u062a \u0639\u0644\u0649 \u0645\u0646 \u0644\u062f\u064a\u0647 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0632\u0648\u0627\u0626\u062f \u0627\u0644\u0644\u062d\u0645\u064a\u0629 \u0627\u0644\u063a\u062f\u064a\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a \u0645\u0639 \u0648\u0631\u0645 \u0641\u064a \u0627\u0644\u0645\u062e \u062e\u0627\u0635\u0629 \u0641\u064a \u0627\u0644\u0645\u062e\u064a\u062e (medullablastoma) \u0639\u0644\u0645\u0627\u064b \u0623\u0646 \u0646\u0641\u0633 \u0627\u0633\u0645 \u0647\u0630\u0647 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062a\u0637\u0644\u0642 \u0639\u0644\u0649 \u0645\u0646 \u0644\u062f\u064a\u0647 \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0644\u064a\u0646\u0634 \u0645\u0639 \u0648\u0631\u0645 \u0641\u064a \u0627\u0644\u0645\u062e \u0644\u0643\u0646 \u0646\u0648\u0639 \u0627\u0644\u0648\u0631\u0645 \u0645\u062e\u062a\u0644\u0641 \u062d\u064a\u062b \u064a\u0643\u0648\u0646 \u0645\u0646 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u062c\u0644\u064a\u0648\u0628\u0644\u0627\u0633\u062a\u0648\u0645\u0627 (Glioblastoma)<\/p>\n

\u0643\u0644 \u0647\u0630\u0647 \u0627\u0644\u0623\u0646\u0648\u0627\u0639 \u0633\u0628\u0628\u0647\u0627 \u062e\u0644\u0644 \u0641\u064a \u062c\u064a\u0646 \u0648\u0627\u062d\u062f \u0627\u0633\u0645\u0647 ( \u0623\u064a \u0628\u064a \u0633\u064a ).<\/p>\n

\u0644\u0630\u0644\u0643 \u0645\u0646 \u0644\u062f\u064a\u0647 \u0637\u0641\u0631\u0629 \u0641\u064a \u062c\u064a\u0646 \u0623\u064a \u0628\u064a \u0633\u064a \u0642\u062f \u064a\u0638\u0647\u0631 \u0639\u0644\u064a\u0647 \u0627\u0648\u0631\u0627\u0645 \u0645\u062e\u062a\u0644\u0641\u0629 \u0648 \u0627\u0646 \u0643\u0627\u0646 \u0627\u0634\u0647\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0627\u062a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648 \u0646\u0633\u0628\u062a \u0627\u062d\u062a\u0645\u0627\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0647 100% \u0642\u0628\u0644 \u0633\u0646 \u0627\u0644\u0627\u0631\u0628\u0639\u064a\u0646 \u0643\u0630\u0644\u0643 \u0647\u0645 \u0645\u0639\u0631\u0636\u0648\u0646 \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0623\u0648\u0631\u0627\u0645 \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 ( \u0627\u062d\u062a\u0645\u0627\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 4% to 12%) \u0648 \u0627\u0644\u0645\u0639\u062f\u0629 (0.5%)\u0648 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 (\u0627\u062d\u062a\u0645\u0627\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 2%) \u0648 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 (2%)\u0648 \u0627\u0644\u0643\u0628\u062f \u0648 \u0645\u062c\u0627\u0631\u064a \u0627\u0644\u0639\u0635\u0627\u0631\u0629 \u0627\u0644\u0635\u0641\u0631\u0627\u0621 (1.5%) \u0648 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0643\u0638\u0631\u064a\u0629 \u0648 \u0627\u0644\u0645\u062e \u062e\u0627\u0635\u0629 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u062e\u064a\u062e. (medullablastoma).<\/p>\n

<\/h3>\n

\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629: \u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0627\u0644\u0632\u0648\u0627\u0626\u062f \u0627\u0644\u0644\u062d\u0645\u064a\u0629 \u0627\u0644\u063a\u062f\u064a\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a (\u0641\u0627\u0628)
\n\u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646 : \u0623\u064a \u0628\u064a \u0633\u064a (APC)
\n\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u0648\u0631\u0627\u0645: \u0628\u0634\u0643\u0644 \u0639\u0627\u0644\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 . \u0628\u0634\u0643\u0644 \u0627\u0642\u0644 \u0627\u0648\u0631\u0627\u0645 \u0641\u064a \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0648\u0627\u0644\u0645\u0639\u062f\u0629 \u0648 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0648 \u0627\u0644\u0645\u062e \u0648 \u0627\u0644\u0639\u0638\u0645 \u0648 \u0627\u0644\u062c\u0644\u062f \u0648 \u0623\u0639\u0636\u0627\u0621 \u0623\u062e\u0631\u0649.<\/h3>\n

\u0646\u0633\u0628 \u0627\u0644\u0625\u0635\u0627\u0628\u0629:<\/h3>\n

\u0646\u0633\u0628\u0629 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0644\u0645\u0646 \u0644\u062f\u064a\u0647 \u0637\u0641\u0631\u0629 \u0641\u064a \u0627\u0644\u062c\u064a\u0646 100% \u0639\u0644\u0649 \u0633\u0646 \u0627\u0644\u0627\u0631\u0628\u0639\u064a\u0646. \u0648 \u0641\u064a \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0645\u0648\u0647\u0646 \u0627\u062d\u062a\u0645\u0627\u0644 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 70 \u0627\u0644\u0649 80% \u0641\u064a \u0633\u0646 \u0627\u0644\u062e\u0645\u0633\u064a\u0646.<\/p>\n

\u0627\u0644\u0646\u0635\u0627\u0626\u062d \u0627\u0644\u0627\u0631\u0634\u0627\u062f\u064a\u0629:<\/h3>\n

\u0645\u0646 \u0644\u062f\u064a\u0647\u0645 \u0637\u0641\u0631\u0629 \u0641\u064a \u0623\u062d\u062f \u0627\u0644\u062c\u064a\u0646 \u064a\u0648\u0635\u0649 \u0628\u0639\u0645\u0644 \u0645\u0627 \u064a\u0644\u064ag :<\/p>\n

\u064a\u0646\u0635\u062d \u0628\u0627\u0644\u0641\u062d\u0635 \u0639\u0646 \u062a\u0648\u0631\u0645\u0627\u062a \u0627\u0644\u0643\u0628\u062f \u062e\u0644\u0627\u0644 \u0627\u0644\u062e\u0645\u0633 \u0633\u0646\u0648\u0627 \u0627\u0644\u0623\u0648\u0644\u0649 \u0644\u0644\u0639\u0645\u0631 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0642\u064a\u0627\u0633 \u0645\u0627\u062f\u0629 \u0627\u0644\u0641\u0627\u0641\u064a\u062a\u0648\u0628\u0631\u0648\u062a\u064a\u0646 \u0643\u0644 \u062b\u0644\u0627\u062b \u0623\u0634\u0647\u0631.<\/p>\n

\u064a\u0646\u0635\u062d \u0628\u0625\u062c\u0631\u0627\u0621 \u0645\u0646\u0638\u0627\u0631 \u0644\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0628\u064a\u0646 \u0633\u0646 \u0627\u0644\u0639\u0627\u0634\u0631\u0629 \u0648\u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0639\u0634\u0631\u0629 \u0645\u0646 \u0627\u0644\u0639\u0645\u0631 \u0633\u0646\u0648\u064a\u0627\u064b.<\/p>\n

\u064a\u0646\u0635\u062d \u0628\u0625\u062c\u0631\u0627\u0621 \u0645\u0646\u0638\u0627\u0631 \u0644\u0644\u0642\u0648\u0644\u0648\u0646 \u0639\u0646\u062f \u0638\u0647\u0648\u0631 \u0623\u064a \u0632\u0648\u0627\u0626\u062f \u0644\u062d\u0645\u064a\u0629 \u0648\u0627\u0633\u062a\u0623\u0635\u0644\u0647\u0627 \u0643\u0630\u0644\u0643 \u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0628\u0634\u0643\u0644 \u0627\u062d\u062a\u0631\u0627\u0632\u064a.<\/p>\n

\u0628\u0639\u062f \u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u064a\u062c\u0628 \u0627\u0644\u0627\u0633\u062a\u0645\u0631\u0627\u0631 \u0641\u064a \u0639\u0645\u0644 \u0645\u0646\u0638\u0627\u0631 \u0644\u0644\u0645\u0633\u062a\u0642\u064a\u0645 \u0627\u0648 \u0627\u0644\u062c\u0632\u0621 \u0627\u0644\u0645\u062a\u0628\u0642\u064a \u0644\u0644\u0642\u0648\u0644\u0648\u0646 \u0643\u0644 6 \u0627\u0644\u0649 12 \u0634\u0647\u0631 \u0648\u0627\u0632\u0627\u0644\u062a \u0623\u064a \u0632\u0648\u0627\u0626\u062f \u0644\u062d\u0645\u064a\u0629.<\/p>\n

\u064a\u0646\u0635\u062d \u0628\u0625\u062c\u0631\u0627\u0621 \u0645\u0646\u0638\u0627\u0631 \u0644\u0644\u0645\u0639\u062f\u0629 \u0643\u0644 \u0633\u0646\u0647 \u0627\u0648 \u062b\u0644\u0627\u062b \u0633\u0646\u0648\u0627\u062a \u0627\u0628\u062a\u062f\u0627\u0621 \u0645\u0646 \u0639\u0645\u0631 25 \u0623\u0648 30 \u0633\u0646\u0647.<\/p>\n

\u064a\u0646\u0635\u062d \u0628\u0639\u0645\u0644 \u0627\u0634\u0639\u0629 \u0645\u0642\u0637\u0639\u064a\u0629 \u0644\u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0644\u0644\u0628\u062d\u062b \u0639\u0646 \u0627\u0644\u062a\u0648\u0631\u0645\u0627\u062a \u0641\u064a \u062d\u0627\u0644 \u0627\u0643\u062a\u0634\u0627\u0641 \u0623\u064a \u062a\u0648\u0631\u0645 \u0639\u0628\u0631 \u0645\u0646\u0638\u0627\u0631 \u0627\u0644\u0645\u0639\u062f\u0629 \u0648\u0642\u0628\u0644 \u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 \u0648\u062a\u0639\u0627\u062f \u0643\u0644 \u0633\u0646\u0647 \u0627\u0644\u0649 \u062b\u0644\u0627\u062b \u0633\u0646\u0648\u0627\u062a.<\/p>\n

\u064a\u0646\u0635\u062d \u0628\u0639\u0645\u0644 \u0627\u0634\u0639\u0629 \u0645\u063a\u0646\u0627\u0637\u064a\u0633\u064a\u0629 \u0627\u0648 \u0645\u0642\u0637\u0639\u064a\u0629 \u0644\u0644\u0628\u0637\u0646 \u0644\u0644\u0628\u062d\u062b \u0639\u0646 \u062a\u0648\u0631\u0645\u0627\u062a \u062f\u0633\u0645\u0648\u064a\u062f (desmoid)\u0644\u0645\u0646 \u0644\u062f\u064a\u0647 \u062a\u0627\u0631\u064a\u062e \u0639\u0627\u0626\u0644\u064a \u0628\u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0647\u0630\u0627 \u0627\u0644\u0648\u0631\u0645 \u0627\u0648 \u0627\u0644\u0637\u0641\u0631\u0629 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u062a\u0632\u064a\u062f \u0645\u0646 \u0627\u062d\u062a\u0645\u0627\u0644\u064a\u0647 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0647.<\/p>\n

\u064a\u0646\u0635\u062d \u0628\u0641\u062d\u0635 \u0627\u0644\u063a\u062f\u0629 \u0644\u062f\u0631\u0642\u064a\u0629 \u0648\u0627\u0644\u062c\u0644\u062f \u0628\u0634\u0643\u0644 \u062f\u0648\u0631\u064a \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u0627\u0643\u0644\u064a\u0646\u064a\u0643\u064a \u0648 \u0627\u0644\u0627\u0634\u0639\u0629 \u0627\u0644\u0635\u0648\u062a\u064a\u0629 \u0644\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0627\u0628\u062a\u062f\u0627\u0621 \u0645\u0646 \u0639\u0645\u0631 25 \u0623\u0648 30 \u0633\u0646\u0647 \u0628\u0634\u0643\u0644 \u0633\u0646\u0648\u064a.<\/p>\n

\u0627\u0644\u0648\u0642\u0627\u064a\u0629:<\/h3>\n

\u0627\u0644\u062a\u062f\u062e\u0644 \u0627\u0644\u062c\u0631\u0627\u062d\u064a \u0627\u0644\u0648\u0642\u0627\u0626\u064a (\u0627\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u0642\u0648\u0644\u0648\u0646) \u064a\u0642\u0644\u0644 \u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646 .\u0645\u0646 \u064a\u0631\u062b \u0646\u0633\u062e\u0629 \u0645\u0639\u0637\u0648\u0628\u0629 (\u0637\u0641\u0631\u0629) \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u062c\u064a\u0646 \u0644\u062f\u064a\u0647 \u0627\u062d\u062a\u0645\u0627\u0644 \u064a\u0635\u0644 \u0627\u0644\u0649 50% \u0644\u062a\u0648\u0631\u064a\u062b\u0647 \u0627\u0644\u0649 \u0627\u062d\u062f \u0627\u0641\u0631\u0627\u062f \u0630\u0631\u064a\u062a\u0647 \u0641\u064a \u0643\u0644 \u062d\u0645\u0644 \u0648 50% \u0627\u062d\u062a\u0645\u0627\u0644 \u0623\u0646 \u064a\u0631\u062b\u0648\u0627 \u0646\u0633\u062e\u0629 \u0633\u0644\u064a\u0645\u0629 \u0645\u0646\u0647 \u0644\u0630\u0644\u0643 \u064a\u0646\u0635\u062d \u0628\u0641\u062d\u0635 \u0627\u0644\u0639\u0627\u0626\u0644\u0629 \u0644\u0644\u0648\u0642\u0627\u064a\u0629.<\/p>\n

<\/h3>\n

\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0625\u0636\u0627\u0641\u064a\u0629:<\/h3>\n\n\n\n\n\n\n
\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629: \u0627\u0644\u0632\u0648\u0627\u0626\u062f \u0627\u0644\u0644\u062d\u0645\u064a\u0629 \u0627\u0644\u063a\u062f\u064a\u0629 \u0627\u0644\u0639\u0627\u0626\u0644\u064a (\u0641\u0627\u0628)
\n\u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646 : APC\u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0623\u0648\u0631\u0627\u0645: \u0628\u0634\u0643\u0644 \u0639\u0627\u0644\u064a \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646. \u0628\u0634\u0643\u0644 \u0627\u0642\u0644 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633 \u0648 \u0627\u0644\u0645\u0639\u062f\u0629 \u0648 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0648 \u0627\u0644\u0645\u062e \u0648 \u0627\u0644\u062c\u0644\u062f \u0648 \u0627\u0644\u0643\u0628\u062f \u0648 \u0642\u0646\u0627\u0629 \u0627\u0644\u0635\u0641\u0631\u0627\u0648\u064a \u0645\u0639 \u0628\u0639\u0636 \u0627\u0644\u062a\u0648\u0631\u0645\u0627\u062a \u0627\u0644\u062c\u0644\u062f\u064a\u0629 \u0648 \u0641\u064a \u0627\u0644\u0627\u0646\u0633\u062c\u0629 \u0641\u064a \u0628\u0639\u0636 \u0627\u0646\u0648\u0627\u0639\u0647. Werathah<\/td>\n<\/tr>\n
\u0623\u0648\u0631\u0627\u0645 \u0627\u062e\u0631\u0649<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0643\u0628\u062f \u0648 \u0627\u0644\u0642\u0646\u0627\u0629 \u0627\u0644\u0635\u0641\u0631\u0627\u0648\u064a\u0629<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u062e<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633<\/b><\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0642\u0648\u0644\u0648\u0646<\/b><\/b><\/td>\n\u0627\u0648\u0631\u0627\u0645 \u0627\u0644\u0623\u0645\u0639\u0627\u0621 \u0627\u0644\u062f\u0642\u064a\u0642\u0629<\/b><\/td>\n\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u0645\u0639\u062f\u0629<\/b><\/td>\n<\/td>\n\u0627\u0633\u0645 \u0627\u0644\u0645\u062a\u0644\u0627\u0632\u0645\u0629 <\/b><\/b><\/td>\n<\/td>\n<\/tr>\n
\n

\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u062c\u0627\u0631\u062f\u0646\u0631 \u064a\u0643\u0648\u0646 \u0645\u0639\u0647\u0627 \u062a\u0648\u0631\u0645\u0627\u062a \u062d\u0645\u064a\u062f\u0629 \u0641\u064a \u0627\u0644\u062c\u0644\u062f \u0648\u0627\u0644\u0627\u0646\u0633\u062c\u0629 \u0645\u0639 \u0627\u062d\u062a\u0645\u0627\u0644 \u062a\u0648\u0631\u0645\u0627\u062a \u0641\u064a \u0623\u062c\u0632\u0627\u0621 \u0639\u062f\u0647 \u0645\u0646 \u0627\u0644\u062c\u0633\u0645.<\/b><\/h3>\n<\/td>\n

x<\/td>\nx<\/td>\nx<\/td>\nx<\/td>\n<\/td>\nX<\/td>\n<\/td>\n\u0627\u0644\u0627\u0646\u0627\u062b<\/b><\/td>\n<\/td>\n<\/tr>\n
x<\/td>\nx<\/td>\nx<\/td>\nx<\/td>\n<\/td>\nx<\/td>\n<\/td>\n\u0627\u0644\u0630\u0643\u0648\u0631<\/b><\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u062a\u0623\u0644\u064a\u0641:<\/b><\/h2>\n

\u0639\u0628\u062f\u0627\u0644\u0631\u062d\u0645\u0646 \u0641\u0627\u064a\u0632 \u0627\u0644\u0633\u0648\u064a\u062f<\/b><\/h2>\n

\u0627\u0633\u062a\u0634\u0627\u0631\u064a \u0627\u0644\u0648\u0631\u0627\u062b\u0629 \u0627\u0644\u0625\u0643\u0644\u064a\u0646\u064a\u0643\u064a\u0629 \u0648\u0637\u0628 \u0627\u0644\u0623\u0637\u0641\u0627\u0644<\/b><\/p>\n

\u0645\u062f\u064a\u0646\u0629 \u0627\u0644\u0645\u0644\u0643 \u0639\u0628\u062f\u0627\u0644\u0639\u0632\u064a\u0632 \u0627\u0644\u0637\u0628\u064a\u0629 \u0628\u0627\u0644\u062d\u0631\u0633 \u0627\u0644\u0648\u0637\u0646\u064a-\u0627\u0644\u0631\u064a\u0627\u0636<\/b><\/p>\n","protected":false},"excerpt":{"rendered":"

\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648\u0627\u0644\u0645\u0628\u064a\u0636 \u0627\u0644\u0648\u0631\u0627\u062b\u064a (Hereditary breast cancer and ovarian cancer syndrome) \u0623\u0634\u0647\u0631 \u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u0628\u0628 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0647\u0648 \u0645\u0627 \u064a\u0639\u0631\u0641 \u0628\u0645\u062a\u0644\u0627\u0632\u0645\u0629 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648\u0627\u0644\u0645\u0628\u064a\u0636 \u0627\u0644\u0648\u0631\u0627\u062b\u064a .\u0647\u0630\u0627 \u0627\u0644\u0646\u0648\u0639 \u0633\u0628\u0628\u0647 \u0637\u0641\u0631\u0629 \u0641\u064a \u0646\u0648\u0639\u064a\u0646 \u0645\u0634\u0647\u0648\u0631\u064a\u0646 \u0645\u0646 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u062a\u0633\u0645\u0649 \u0628\u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0623\u0648\u0644 \u0648 \u0627\u0644\u062b\u0627\u0646\u064a \u0645\u0646 \u0628\u064a \u0623\u0631 \u0633\u064a \u0623\u064a (BRCA1 and BRCA2) \u0648 \u0647\u064a \u062c\u064a\u0646\u0627\u062a \u0645\u0647\u0645\u0629 …<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[10],"tags":[38,34,39,35,40,37,36,11,22,20,30,12,26,27,24,14,32,31,15,19,25,21,29,23,28,13,16,33,17,18],"class_list":["post-172","post","type-post","status-publish","format-standard","hentry","category-cancer-syndromes","tag-breast","tag-cancer","tag-colon","tag-genetic","tag-ovarian","tag-syndrome","tag-testing","tag-11","tag-22","tag-20","tag-30","tag-12","tag-26","tag-27","tag-24","tag-14","tag-32","tag-31","tag-15","tag-19","tag-25","tag-21","tag-29","tag-23","tag-28","tag-13","tag-16","tag--arabic","tag-17","tag-18"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/werathah.com\/cancer\/wp-json\/wp\/v2\/posts\/172","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/werathah.com\/cancer\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/werathah.com\/cancer\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/werathah.com\/cancer\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/werathah.com\/cancer\/wp-json\/wp\/v2\/comments?post=172"}],"version-history":[{"count":6,"href":"https:\/\/werathah.com\/cancer\/wp-json\/wp\/v2\/posts\/172\/revisions"}],"predecessor-version":[{"id":321,"href":"https:\/\/werathah.com\/cancer\/wp-json\/wp\/v2\/posts\/172\/revisions\/321"}],"wp:attachment":[{"href":"https:\/\/werathah.com\/cancer\/wp-json\/wp\/v2\/media?parent=172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/werathah.com\/cancer\/wp-json\/wp\/v2\/categories?post=172"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/werathah.com\/cancer\/wp-json\/wp\/v2\/tags?post=172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}